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1. Safety and immunogenicity of a single dose of a tetravalent dengue vaccine with two different serotype-2 potencies in adults in Singapore: A phase 2, double-blind, randomised, controlled trial

Author:
Tricou, Vianney; Low, Jenny G.; Oh, Helen M.; Leo, Yee-Sin; Kalimuddin, Shirin; Wijaya, Limin; Pang, Junxiong; Ling, Li Min; Lee, Tau Hong; Brose, Manja; Hutagalung, Yanee; Rauscher, Martina; Borkowski, Astrid; Wallace, Derek
Source:
Vaccine 2020 v.38 no.6 pp. 1513-1519
ISSN:
0264-410X
Subject:
viremia,   etc   ; adults; dengue; immunogenicity; neutralizing antibodies; seroprevalence; serotypes; vaccination; vaccines; Singapore;     Show all 10 Subjects
Abstract:
... Early formulations of Takeda’s tetravalent dengue vaccine candidate (TAK-003) have demonstrated notably higher neutralizing antibody responses against serotype 2 than other serotypes. Here, we assessed the immunogenicity and tolerability in adults living in Singapore of two TAK-003 formulations: an early formulation, referred to as HD-TDV, and a new formulation with 10-fold lower serotype 2 potenc ...
DOI:
10.1016/j.vaccine.2019.11.061

2. A comparison of commercial modified-live PRRSV-1 and PRRSV-2 vaccines against a dual heterologous PRRSV-1 and PRRSV-2 challenge in late term pregnancy gilts

Author:
Yang, Siyeon; Oh, Taehwan; Cho, Hyejean; Chae, Chanhee
Source:
Comparative immunology, microbiology, and infectious diseases 2020 v.69 pp. 101423
ISSN:
0147-9571
Subject:
viremia,   etc   ; Porcine reproductive and respiratory syndrome virus; breeding; gilts; interferon-gamma; piglets; pregnancy; reproductive performance; sows; vaccination; vaccines; viability; viruses;     Show all 13 Subjects
Abstract:
... This study compared the efficacy, in terms of reproductive performance, of a porcine reproductive and respiratory syndrome virus (PRRSV)-1 or PRRSV-2 modified-live virus (MLV) vaccine against a dual heterologous PRRSV-1 and PRRSV-2 challenge. Gilts were administered either the PRRSV-1 or PRRSV-2 MLV vaccine at 21 days prior to breeding and were challenged intranasally with both PRRSV species at da ...
DOI:
10.1016/j.cimid.2020.101423

3. Do porcine parvoviruses 1 through 7 (PPV1-PPV7) have an impact on porcine circovirus type 2 (PCV2) viremia in pigs?

Author:
Miłek, Dagmara; Woźniak, Aleksandra; Podgórska, Katarzyna; Stadejek, Tomasz
Source:
Veterinary microbiology 2020 v.242 pp. 108613
ISSN:
0378-1135
Subject:
viremia,   etc   ; Porcine circovirus-2; Ungulate protoparvovirus 1; blood serum; farms; mixed infection; quantitative polymerase chain reaction; swine;     Show all 8 Subjects
Abstract:
... Infections with porcine parvoviruses 1 through 7 (PPV1-PPV7) and porcine circovirus type 2 (PCV2) are widespread in pig population. PCV2 is involved in a number of disease syndromes collectively called PCV2‐associated diseases (PCVD). It is well elucidated, that PPV1 may act as a triggering factor of PCVD through supporting PCV2 replication. Less is known about the PPV2-PPV7 impact on PCV2 viremia ...
DOI:
10.1016/j.vetmic.2020.108613

4. Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody

Author:
Schommers, Philipp; Gruell, Henning; Abernathy, Morgan E.; Tran, My-Kim; Dingens, Adam S.; Gristick, Harry B.; Barnes, Christopher O.; Schoofs, Till; Schlotz, Maike; Vanshylla, Kanika; Kreer, Christoph; Weiland, Daniela; Holtick, Udo; Scheid, Christof; Valter, Markus M.; van Gils, Marit J.; Sanders, Rogier W.; Vehreschild, Jörg J.; Cornely, Oliver A.; Lehmann, Clara; Fätkenheuer, Gerd; Seaman, Michael S.; Bloom, Jesse D.; Bjorkman, Pamela J.; Klein, Florian
Source:
Cell 2020 v.180 no.3 pp. 471-489.e22
ISSN:
0092-8674
Subject:
viremia,   etc   ; HIV infections; Human immunodeficiency virus 1; binding sites; broadly neutralizing antibodies; glycoproteins; inhibitory concentration 50; mice; mutation; therapeutics;     Show all 10 Subjects
Abstract:
... Broadly neutralizing antibodies (bNAbs) represent a promising approach to prevent and treat HIV-1 infection. However, viral escape through mutation of the HIV-1 envelope glycoprotein (Env) limits clinical applications. Here we describe 1-18, a new VH1-46-encoded CD4 binding site (CD4bs) bNAb with outstanding breadth (97%) and potency (GeoMean IC₅₀ = 0.048 μg/mL). Notably, 1-18 is not susceptible t ...
DOI:
10.1016/j.cell.2020.01.010
PubMed:
32004464
PubMed Central:
PMC7042716

5. Ultra-low HIV-1 p24 detection limits with a bioelectronic sensor

Author:
Macchia, Eleonora; Sarcina, Lucia; Picca, Rosaria Anna; Manoli, Kyriaki; Di Franco, Cinzia; Scamarcio, Gaetano; Torsi, Luisa
Source:
Analytical and bioanalytical chemistry 2020 v.412 no.4 pp. 811-818
ISSN:
1618-2642
Subject:
viremia,   etc   ; Human immunodeficiency virus 1; antibodies; biomarkers; coat proteins; detection limit; early diagnosis; point-of-care systems; screening; therapeutics; transistors;     Show all 11 Subjects
Abstract:
... Early diagnosis of the infection caused by human immunodeficiency virus type-1 (HIV-1) is vital to achieve efficient therapeutic treatment and limit the disease spreading when the viremia is at its highest level. To this end, a point-of-care HIV-1 detection carried out with label-free, low-cost, and ultra-sensitive screening technologies would be of great relevance. Herein, a label-free single mol ...
DOI:
10.1007/s00216-019-02319-7
PubMed:
31865415
PubMed Central:
PMC7005089

6. Yellow fever epizootics in non-human primates, Southeast and Northeast Brazil (2017 and 2018)

Author:
Mares-Guia, Maria Angélica Monteiro de Mello; Horta, Marco A.; Romano, Alessandro; Rodrigues, Cíntia D. S.; Mendonça, Marcos C. L.; dos Santos, Carolina C.; Torres, Maria C.; Araujo, Eliane S. M.; Fabri, Allison; de Souza, Everton R.; Ribeiro, Roberta O. R.; Lucena, Fabiana P.; Junior, Luiz C. A.; da Cunha, Rivaldo V.; Nogueira, Rita M. R.; Sequeira, Patricia C.; de Filippis, Ana M. Bispo
Source:
Parasites & vectors 2020 v.13 no.1 pp. 90
ISSN:
1756-3305
Subject:
viremia,   etc   ; Alouatta; Callithrix; Yellow fever virus; diagnostic techniques; epizootic diseases; humans; monitoring; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; vaccination; virus transmission; yellow fever; Brazil;     Show all 14 Subjects
Abstract:
... BACKGROUND: Yellow fever (YF) is a severe, infectious, but non-communicable arboviral hemorrhagic disease. In the last decades, yellow fever virus (YFV) infections have been prevalent in endemic areas in Brazil, affecting human and non-human primate (NHP) populations. Monitoring of NHP infection started in 1999, and reports of epizootic diseases are considered important indicators of viral transmi ...
DOI:
10.1186/s13071-020-3966-x
PubMed:
32075684
PubMed Central:
PMC7031979

7. Identification and pathogenicity of a novel genotype avian hepatitis E virus from silkie fowl (gallus gallus)

Author:
Liu, Baoyuan; Chen, Yiyang; Zhao, Liang; Zhang, Meimei; Ren, Xiaolei; Zhang, Yuan; Zhang, Beibei; Fan, Mengnan; Zhao, Qin; Zhou, En-Min
Source:
Veterinary microbiology 2020 v.245 pp. 108688
ISSN:
0378-1135
Subject:
viremia,   etc   ; Gallus gallus; Orthohepevirus A; Orthohepevirus B; alanine transaminase; amino acids; chickens; endoplasmic reticulum; genetic variation; genome; genotype; hosts; liver; mitochondria; pathogenicity; public health; seroconversion; viral shedding; zoonoses;     Show all 19 Subjects
Abstract:
... Hepatitis E virus (HEV) is a public health concern because of its zoonotic potential; however, the host species spectrum and the genetic diversity of HEV in many birds are unknown. In the present study, a novel genotype avian HEV was isolated from a bird, silkie fowl, and designated CHN-GS-aHEV (GenBank No. MN562265). The genome of CHN-GS-aHEV was analyzed in comparison with other avian HEVs’ and ...
DOI:
10.1016/j.vetmic.2020.108688

8. Prevalence of equine hepacivirus infection in Mongolia

Author:
Date, Tomoko; Sugiyama, Masaya; Lkhagvasuren, Damdindorj; Wakita, Takaji; Oyunsuren, Tsendsuren; Mizokami, Masashi
Source:
Virus research 2020 v.282 pp. 197940
ISSN:
0168-1702
Subject:
viremia,   etc   ; 5' untranslated regions; Hepatitis C virus; blood sampling; blood serum; chronic diseases; genetic variation; genome; horses; human diseases; humans; mutation; phylogeny; subgenotype; viruses; Europe; Mongolia; North America;     Show all 18 Subjects
Abstract:
... Equine hepacivirus (EHV) belongs to the hepacivirus A and is related to hepatitis C virus (HCV). This virus shows hepatic tropism and is known to chronically infect horses. EHV has been reported from various countries, but the prevalence in Mongolia, where large horse populations are pastured, remains unknown. This study collected serum samples from horses in six areas across Mongolia, in order to ...
DOI:
10.1016/j.virusres.2020.197940

9. Recombinant Erns-E2 protein vaccine formulated with MF59 and CPG-ODN promotes T cell immunity against bovine viral diarrhea virus infection

Author:
Wang, Shenghua; Yang, Guanghui; Nie, Jiawei; Yang, Renjie; Du, Mengze; Su, Jinhui; Wang, Jing; Wang, Jiufeng; Zhu, Yaohong
Source:
Vaccine 2020 v.38 no.22 pp. 3881-3891
ISSN:
0264-410X
Subject:
viremia,   etc   ; Bovine viral diarrhea virus 1; T-lymphocytes; antibodies; cattle industry; cell-mediated immunity; immunization; immunogenicity; interleukin-4; mice; oligodeoxyribonucleotides; plasmids; vaccine adjuvants; vaccines;     Show all 14 Subjects
Abstract:
... To obtain an effective vaccine candidate against bovine viral diarrhea virus (BVDV) disease which causes great economical loss in cattle industries, recombinant Eʳⁿˢ-E2 protein vaccine containing MF59 and CPG-ODN adjuvants was prepared and assessed in this study. The recombinant plasmid (pET32a-Eʳⁿˢ-E2) was constructed and transformed into BL21 (DE3) cells to produce Eʳⁿˢ-E2 protein. We immunized ...
DOI:
10.1016/j.vaccine.2020.03.020

10. Development of a quantitative real-time RT-PCR assay that differentiates between Kyasanur Forest disease virus and Alkhurma hemorrhagic fever virus

Author:
N, Sudheesh; Hewson, Roger; Afrough, Babak; Bewley, Kevin; Arunkumar, Govindakarnavar
Source:
Ticks and tick-borne diseases 2020 v.11 no.3 pp. 101381
ISSN:
1877-959X
Subject:
viremia,   etc   ; Kyasanur Forest disease virus; blood sampling; enzootic diseases; hosts; humans; monkeys; pathogen identification; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; tick-borne diseases; ticks; India;     Show all 13 Subjects
Abstract:
... Kyasanur Forest disease virus (KFDV) and Alkhurma hemorrhagic fever virus (AHFV) are enveloped, positive-stranded RNA viruses of clinical importance with complex enzootic life cycles involving hematophagous ticks which feed on small and large mammals. Humans and monkeys are dead-end hosts for these viruses. Recent trends in epidemiological data suggest both virus incidences are steadily increasing ...
DOI:
10.1016/j.ttbdis.2020.101381

11. Longitudinal study of BK Polyomavirus outcomes, risk factors, and kinetics in renal transplantation patients

Author:
Chan, Brandon Dow; Wong, Gabriella; Jiang, Qing; Lee, Magnolia Muk-Lan; Wong, Wing-Yan; Chen, Feifei; Wong, Wing-Tak; Zhu, Lixing; Wong, Francis Kim-Ming; Tai, William Chi-Shing
Source:
Microbial pathogenesis 2020 v.142 pp. 104036
ISSN:
0882-4010
Subject:
viremia,   etc   ; Human polyomavirus 1; diabetes; hyperlipidemia; immunoglobulins; intravenous injection; kidney diseases; kidney transplant; longitudinal studies; observational studies; patients; quantitative polymerase chain reaction; renal function; risk factors; viral load;     Show all 15 Subjects
Abstract:
... In the immunocompromised conditions following renal transplantation, BK virus can reactivate and cause BK virus associated nephropathy (BKVN). Increased BK viral loads and extended duration of infection have been linked to development of BKVN. The aim of this study was to observe the incidence of BKV infection and BKVN, and kinetics of infection and disease in renal transplantation recipients.From ...
DOI:
10.1016/j.micpath.2020.104036

12. Inapparent dengue in a community living among dengue-positive Aedes mosquitoes and in a hospital in Klang Valley, Malaysia

Author:
Tan, Wing; Liew, Jonathan Wee Kent; Selvarajoo, Sivaneswari; Lim, Xin Ying; Foo, Chuan Jie; Refai, Wardha F.; Robson, Noorzurani; Othman, Sajaratulnisah; Hadi, Haireen Abdul; Mydin, Fadzilah Hanum Mohd; Malik, Tun Firzara Abdul; Lau, Yee Ling; Vythilingam, Indra
Source:
Acta tropica 2020 v.204 pp. 105330
ISSN:
0001-706X
Subject:
viremia,   etc   ; Aedes; RNA; antigens; control methods; dengue; diagnostic techniques; endemic diseases; health care workers; hospitals; humans; immunoglobulin G; immunoglobulin M; monitoring; patients; public health; seroprevalence; Malaysia;     Show all 18 Subjects
Abstract:
... The public health burden of dengue is most likely under reported. Current dengue control measures only considered symptomatic dengue transmission. Hence, there is a paucity of information on the epidemiology of inapparent dengue. This study reports that many people have been unknowingly exposed to dengue infection. Almost 10% and 70% of individuals without any history of dengue infection and livin ...
DOI:
10.1016/j.actatropica.2020.105330

13. Pathogenesis of Thai duck Tembusu virus in Cherry Valley ducks: The effect of age on susceptibility to infection

Author:
Ninvilai, Patchareeporn; Limcharoen, Benchaphorn; Tunterak, Wikanda; Prakairungnamthip, Duangduean; Oraveerakul, Kanisak; Banlunara, Wijit; Thontiravong, Aunyaratana
Source:
Veterinary microbiology 2020 v.243 pp. 108636
ISSN:
0378-1135
Subject:
viremia,   etc   ; Tembusu virus; adults; bird diseases; ducks; egg production; monitoring; morbidity; mortality; neutralizing antibodies; pathogenesis; signs and symptoms (animals and humans); tissues; viral load;     Show all 14 Subjects
Abstract:
... Several duck Tembusu virus (DTMUV) clusters have been identified since its first emergence in 2010. However, the pathogenesis evaluation of DTMUV has been restricted to cluster 2.2 Chinese DTMUVs. In this study, the pathogenesis of a cluster 2.1 Thai DTMUV was investigated in three ages of Cherry Valley ducks (1-, 4- and 27-week-old). In each age, 35 ducks were inoculated with a cluster 2.1 Thai D ...
DOI:
10.1016/j.vetmic.2020.108636

14. Prior vaccination with recombinant Vesicular Stomatitis Virus – Zaire Ebolavirus vaccine is associated with improved survival among patients with Ebolavirus infection

Author:
Kasereka, Masumbuko Claude; Ericson, Austin D.; Conroy, Andrea L.; Tumba, Lukaba; Mwesha, Ombeni Didier; Hawkes, Michael T.
Source:
Vaccine 2020 v.38 no.14 pp. 3003-3007
ISSN:
0264-410X
Subject:
viremia,   etc   ; Vesiculovirus; Zaire Ebola virus; acute kidney injury; hospitals; longitudinal studies; mortality; observational studies; patients; vaccination; vaccines; viral load; Democratic Republic of the Congo;     Show all 13 Subjects
Abstract:
... The second largest Ebolavirus disease (EVD) outbreak ever recorded is currently ongoing in Eastern Democratic Republic of the Congo (DRC). This is the first outbreak for which the recombinant Vesicular Stomatitis Virus – Zaire Ebolavirus (rVSV-ZEBOV) candidate vaccine has been widely administered, using a ring vaccination strategy. We examined whether prior vaccination with rVSV-ZEBOV impacts vira ...
DOI:
10.1016/j.vaccine.2020.02.044

15. Alternative methods to reduce the animal use in quality controls of inactivated BTV8 Bluetongue vaccines

Author:
Luciani, Mirella; Di Febo, Tiziana; Ronchi, Gaetano Federico; Sacchini, Flavio; Rossi, Emanuela; Ulisse, Simonetta; Di Pancrazio, Chiara; Antonucci, Daniela; Salini, Romolo; Teodori, Liana; Podaliri Vulpiani, Michele; Tittarelli, Manuela; Di Ventura, Mauro
Source:
Preventive veterinary medicine 2020 v.176 pp. 104923
ISSN:
0167-5877
Subject:
viremia,   etc   ; Bluetongue virus; animal use reduction; antibodies; blood cells; bluetongue; body temperature; enzyme-linked immunosorbent assay; humoral immunity; inactivated vaccines; interleukin-4; markets; quality control; serology; serotypes; sheep;     Show all 16 Subjects
Abstract:
... The acceptance of serology data instead of challenge for market release of new batches of commercial vaccine is under evaluation by regulatory agencies in order to reduce the use of animals and costs for manufacturers. In this study two vaccines for Bluetongue virus serotype 8 were submitted to quality controls required by the European Pharmacopoeia and tested on sheep in comparison with a commerc ...
DOI:
10.1016/j.prevetmed.2020.104923

16. Antibodies to Epizootic Hemorrhagic Disease Virus (EHDV) in Farmed and Wild Florida White-Tailed Deer (Odocoileus virginianus)

Author:
Cauvin, Allison; Dinh, Emily T. N.; Orange, Jeremy P.; Shuman, Rebecca M.; Blackburn, Jason K.; Wisely, Samantha M.
Source:
Journal of wildlife diseases 2020 v.56 no.1 pp. 208-213
ISSN:
0090-3558
Subject:
viremia,   etc   ; Cervus canadensis; Epizootic hemorrhagic disease virus; Odocoileus virginianus; antibodies; deer; elks; farms; genetic factors; herds; livestock and meat industry; public lands; seroprevalence; serotypes; vector control; wildlife; Florida;     Show all 17 Subjects
Abstract:
... The transmission of multiple serotypes of epizootic hemorrhagic disease virus (EHDV) between farmed and free-ranging wildlife is of interest to livestock industries and natural resource agencies. We compared the seroprevalence of EHDV-1, -2, and -6 in wild and farmed white-tailed deer (Odocoileus virginianus) herds in Florida, US. We compared serological prevalence, circulating serotypes, antibody ...
DOI:
10.7589/2019-02-034

17. Effectiveness of a commercial porcine reproductive and respiratory syndrome virus (PRRSV) subunit vaccine against heterologous PRRSV-1 and PRRSV-2 challenge in late-term pregnant gilts

Author:
Oh, T.; Kim, H.; Park, K. H.; Jeong, J.; Kang, I.; Yang, S.; Chae, C.
Source:
Canadian journal of veterinary research 2019 v.83 no.4 pp. 248-254
ISSN:
0830-9000
Subject:
viremia,   etc   ; Porcine reproductive and respiratory syndrome virus; antibodies; genotype; gilts; pregnancy; subunit vaccines; vaccination; veterinary medicine;     Show all 9 Subjects
Abstract:
... The objective of the present study was to evaluate the efficacy of a commercial porcine reproductive and respiratory syndrome virus (PRRSV) subunit vaccine against heterologous PRRSV-1 and PRRSV-2 challenge in late-term pregnant gilts. Gilts were vaccinated intramuscularly 56 and 35 days antepartum (on days 58 and 79 of gestation) and challenged intranasally 21 days antepartum (on day 93 of gestat ...

18. Does porcine circovirus type 3 (PCV3) interfere with porcine circovirus type 2 (PCV2) vaccine efficacy?

Author:
Woźniak, Aleksandra; Miłek, Dagmara; Bąska, Piotr; Stadejek, Tomasz
Source:
Transboundary and emerging diseases 2019 v.66 no.4 pp. 1454-1461
ISSN:
1865-1674
Subject:
viremia,   etc   ; Porcine circovirus-2; Porcine circovirus-3; blood serum; emerging diseases; farms; genome; pathogens; swine; vaccines;     Show all 10 Subjects
Abstract:
... PCV2 is globally spread pathogen involved in a number of diseases (PCVD). Commonly used vaccines against PCV2 are proved to be highly efficacious. The role of recently discovered PCV3 for pig health and interference with PCV2 remains unknown. The study performed on serum samples from seven farms vaccinated against PCV2 and four non‐vaccinated showed very low prevalence of PCV2 viremia in the forme ...
DOI:
10.1111/tbed.13221

19. Comparison of 4 commercial modified-live porcine reproductive and respiratory syndrome virus (PRRSV) vaccines against heterologous Korean PRRSV-1 and PRRSV-2 challenge

Author:
Oh, T.; Kim, H.; Park, K. H.; Yang, S.; Jeong, J.; Kim, S.; Kang, I.; Park, S. J.; Chae, C.
Source:
Canadian journal of veterinary research 2019 v.83 no.1 pp. 57-67
ISSN:
0830-9000
Subject:
viremia,   etc   ; Porcine reproductive and respiratory syndrome virus; lungs; swine; vaccination; vaccines; virology;     Show all 7 Subjects
Abstract:
... The efficacy of 4 commercial porcine reproductive and respiratory syndrome virus (PRRSV) modified-live vaccines (MLV), against PRRSV-1 and PRRSV-2 was evaluated and compared in growing pigs. Two of the vaccines were based on PRRSV-1 and two on PRRSV-2. There were no significant differences between each of the two PRRSV-1 MLV vaccines and the two PRRSV-2 MLV vaccines respectively based on virology, ...

20. Effect of polymorphisms in porcine guanylate-binding proteins on host resistance to PRRSV infection in experimentally challenged pigs

Author:
Khatun, Amina; Nazki, Salik; Jeong, Chang-Gi; Gu, Suna; Mattoo, Sameer ul Salam; Lee, Sim-In; Yang, Myun-Sik; Lim, Byeonghwi; Kim, Kwan-Suk; Kim, Bumseok; Lee, Kyoung-Tae; Park, Choi-Kyu; Lee, Sang-Myeong; Kim, Won-Il
Source:
Veterinary research 2020 v.51 no.1 pp. 14
ISSN:
1297-9716
Subject:
viremia,   etc   ; Porcine reproductive and respiratory syndrome virus; T-lymphocytes; blood serum; cytokines; cytotoxicity; disease resistance; flow cytometry; heterozygosity; homozygosity; immune response; interferon-alpha; lungs; lymph nodes; porcine reproductive and respiratory syndrome; proteins; swine; tonsils; viral load; weight gain;     Show all 20 Subjects
Abstract:
... Guanylate-binding proteins (GBP1 and GBP5) are known to be important for host resistance against porcine reproductive and respiratory syndrome virus (PRRSV) infection. In this study, the effects of polymorphisms in GBP1 (GBP1E2 and WUR) and GBP5 on host immune responses against PRRSV were investigated to elucidate the mechanisms governing increased resistance to this disease. Seventy-one pigs [pre ...
DOI:
10.1186/s13567-020-00745-5
PubMed:
32075688
PubMed Central:
PMC7031929