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1. Identification of novel human adenovirus candidates using the coxsackievirus and adenovirus receptor for cell entry

Author:
Mese, Kemal; Bunz, Oskar; Schellhorn, Sebastian; Volkwein, Wolfram; Jung, Dominik; Gao, Jian; Zhang, Wenli; Baiker, Armin; Ehrhardt, Anja
Source:
Virology journal 2020 v.17 no.1 pp. 52
ISSN:
1743-422X
Subject:
virion,   etc   ; Human mastadenovirus C; animal viruses; humans; luciferase; pathogenesis; patients; polymerase chain reaction; screening; transgenes; viruses;     Show all 11 Subjects
Abstract:
... BACKGROUND: There are over 100 known human adenovirus (HAdV) types, which are able to cause a broad variety of different self-limiting but also lethal diseases especially in immunocompromised patients. Only limited information about the pathogenesis and biology of the majority of these virus types is available. In the present study, we performed a systematic screen for coxsackievirus and adenoviru ...
DOI:
10.1186/s12985-020-01318-w
PubMed:
32272960
PubMed Central:
PMC7146880

2. Determination of Air Filter Anti-Viral Efficiency against an Airborne Infectious Virus

Author:
Park, Dae Hoon; Joe, Yun Haeng; Piri, Amin; An, Sanggwon; Hwang, Jungho
Source:
Journal of hazardous materials 2020 v.396 pp. 122640
ISSN:
0304-3894
Subject:
virion,   etc   ; air; air filters; air flow; anti-infective agents; inhalation exposure; respiratory tract diseases; viruses;     Show all 8 Subjects
Abstract:
... Recently, various studies have reported the prevention and treatment of respiratory infection outbreaks caused by lethal viruses. Consequently, a variety of air filters coated with antimicrobial agents have been developed to capture and inactivate virus particles in continuous airflow conditions. However, since aerosolized infectious viral-testing is inadvisable due to safety concerns, their anti- ...
DOI:
10.1016/j.jhazmat.2020.122640
PubMed:
32339873
PubMed Central:
PMC7152926

3. Genomic characterization of a novel virulent phage infecting Shigella fiexneri and isolated from sewage

Author:
Lu, Han; Yan, Peihan; Xiong, Wenbin; Wang, Jingwei; Liu, Xinchun
Source:
Virus research 2020 v.283 pp. 197983
ISSN:
0168-1702
Subject:
virion,   etc   ; Podoviridae; Shigella; genes; genomics; growth curves; phage therapy; phages; sewage; virulence;     Show all 10 Subjects
Abstract:
... Shigella fiexneri phage SGF2 is a novel lytic phage isolated from a sewage sample. Morphological characterization indicates that phage SGF2 is a member of the Podoviridae family, producing virions with an isometric head (82.6 ± 8 nm diameter) and a short non-contractile tail (length 52 ± 8 nm). This phage specifically infected the Shigella fiexneri. One-step growth curves indicated that the burst ...
DOI:
10.1016/j.virusres.2020.197983

4. Suppression of µ1 subunit of the adaptor protein complex 2 reduces dengue virus release

Author:
Tongmuang, Nopprarat; Yasamut, Umpa; Noisakran, Sansanee; Sreekanth, Gopinathan Pillai; Yenchitsomanus, Pa-thai; Limjindaporn, Thawornchai
Source:
Virus genes 2020 v.56 no.1 pp. 27-36
ISSN:
0920-8569
Subject:
virion,   etc   ; Dengue virus; RNA; clathrin; endocytosis; exocytosis; gene silencing; phosphorylation; protein kinases; serotypes; transfection; viral load;     Show all 12 Subjects
Abstract:
... Dengue virus (DENV) requires clathrin-mediated endocytosis for its entry into the cells where the adaptor protein complex (AP) is vital for the clathrin-coated vesicle formation. The role of AP-2 was previously examined in the early stages of DENV infection; however, the role of AP-2 in the late stage of DENV infection was not determined. The µ1 subunit of AP-2 (AP2M1) is one of the most important ...
DOI:
10.1007/s11262-019-01710-x

5. Viral metagenomic analysis of the cheese surface: A comparative study of rapid procedures for extracting viral particles

Author:
Dugat-Bony, Eric; Lossouarn, Julien; De Paepe, Marianne; Sarthou, Anne-Sophie; Fedala, Yasmina; Petit, Marie-Agnès; Chaillou, Stéphane
Source:
Food microbiology 2020 v.85 pp. 103278
ISSN:
0740-0020
Subject:
virion,   etc   ; DNA; cheeses; chloroform; comparative study; ecosystems; feces; fermented foods; filtration; metagenomics; microbial communities; phages; ultracentrifugation;     Show all 13 Subjects
Abstract:
... The structure and functioning of microbial communities from fermented foods, including cheese, have been extensively studied during the past decade. However, there is still a lack of information about both the occurrence and the role of viruses in modulating the function of this type of spatially structured and solid ecosystems. Viral metagenomics was recently applied to a wide variety of environm ...
DOI:
10.1016/j.fm.2019.103278

6. Mobile Loops and Electrostatic Interactions Maintain the Flexible Tail Tube of Bacteriophage Lambda

Author:
Campbell, Patricia L.; Duda, Robert L.; Nassur, Jamie; Conway, James F.; Huet, Alexis
Source:
Journal of molecular biology 2020 v.432 no.2 pp. 384-395
ISSN:
0022-2836
Subject:
virion,   etc   ; DNA; amino acid sequences; bacteria; bacteriophages; capsid; cryo-electron microscopy; electrostatic interactions; models;     Show all 9 Subjects
Abstract:
... The long flexible tail tube of bacteriophage lambda connects its capsid to the tail tip. On infection, a DNA ejection signal is passed from the tip, along the tube to the capsid that triggers passage of the DNA down the tube and into the host bacterium. The tail tube is built from repeating units of the major tail protein, gpV, which has two distinctive domains. Its N-terminal domain has the same ...
DOI:
10.1016/j.jmb.2019.10.031

7. Quercetin pentaacetate inhibits in vitro human respiratory syncytial virus adhesion

Author:
Lopes, Bruno Rafael Pereira; da Costa, Mirian Feliciano; Genova Ribeiro, Amanda; da Silva, Tiago Francisco; Lima, Caroline Sprengel; Caruso, Icaro Putinhon; de Araujo, Gabriela Campos; Kubo, Leticia Hiromi; Iacovelli, Federico; Falconi, Mattia; Desideri, Alessandro; de Oliveira, Juliana; Regasini, Luis Octavio; de Souza, Fatima Pereira; Toledo, Karina Alves
Source:
Virus research 2020 v.276 pp. 197805
ISSN:
0168-1702
Subject:
virion,   etc   ; Human orthopneumovirus; acetylation; adhesion; children; cytotoxicity; elderly; energy; etiological agents; quercetin; respiratory system; solubility; vaccines;     Show all 13 Subjects
Abstract:
... Human respiratory syncytial virus (hRSV) is one of the main etiological agents of diseases of the lower respiratory tract and is often responsible for the hospitalization of children and the elderly. To date, treatments are only palliative and there is no vaccine available. Natural products show exceptional structural diversity and they have played a vital role in drug research. Several investigat ...
DOI:
10.1016/j.virusres.2019.197805

8. Influenza A Virus Hemagglutinin–Neuraminidase–Receptor Balance: Preserving Virus Motility

Author:
de Vries, Erik; Du, Wenjuan; Guo, Hongbo; de Haan, Cornelis A.M.
Source:
Trends in microbiology 2020 v.28 no.1 pp. 57-67
ISSN:
0966-842X
Subject:
virion,   etc   ; Influenza A virus; epithelial cells; hemagglutinins; hosts; mucus; sialic acid; sialidase;     Show all 8 Subjects
Abstract:
... Influenza A viruses (IAVs) occasionally cross the species barrier and adapt to novel host species. This requires readjustment of the functional balance of the sialic acid receptor-binding hemagglutinin (HA) and the receptor-destroying neuraminidase (NA) to the sialoglycan-receptor repertoire of the new host. Novel techniques have revealed mechanistic details of this HA–NA–receptor balance, emphasi ...
DOI:
10.1016/j.tim.2019.08.010
PubMed:
31629602
PubMed Central:
PMC7172302

9. Look Who’s Talking: T-Even Phage Lysis Inhibition, the Granddaddy of Virus-Virus Intercellular Communication Research

Author:
Abedon, Stephen T.
Source:
Viruses 2019 v.11 no.10
ISSN:
1999-4915
Subject:
virion,   etc   ; bacteria; cell communication; molecular biology; phages;     Show all 5 Subjects
Abstract:
... That communication can occur between virus-infected cells has been appreciated for nearly as long as has virus molecular biology. The original virus communication process specifically was that seen with T-even bacteriophages—phages T2, T4, and T6—resulting in what was labeled as a lysis inhibition. Another proposed virus communication phenomenon, also seen with T-even phages, can be described as a ...
DOI:
10.3390/v11100951
PubMed:
31623057
PubMed Central:
PMC6832632

10. Overcoming the Challenges of Symmetry Reveals New Insights into Herpesvirus Biology

Author:
Bhella, David
Source:
Cell 2019 v.178 no.6 pp. 1277-1279
ISSN:
0092-8674
Subject:
virion,   etc   ; Gammaherpesvirinae; infection; sarcoma; Sub-Saharan Africa;     Show all 5 Subjects
Abstract:
... The oncogenic gammaherpesvirus Kaposi sarcoma-associated herpesvirus (KSHV) is globally widespread; infection rates are as high as 80% in parts of sub-Saharan Africa. In this issue of Cell, Gong et al. (2019) describe the high-resolution structure of a critical component of the KSHV virion—the portal vertex. ...
DOI:
10.1016/j.cell.2019.08.017

11. Genome analysis of Crassaminicella sp. SY095, an anaerobic mesophilic marine bacterium isolated from a deep-sea hydrothermal vent on the Southwest Indian Ridge

Author:
Li, Xue-Gong; Zhang, Wei-Jia; Qi, Xiao-Qing; Wu, Long-Fei
Source:
Marine genomics 2020 v.52 pp. 100733
ISSN:
1874-7787
Subject:
virion,   etc   ; amino acid metabolism; aquatic bacteria; chromosomes; genes; nucleotide sequences; peptides; plasmids; ribosomal RNA; sequence analysis; sporulation; transfer RNA;     Show all 12 Subjects
Abstract:
... Crassaminicella sp. strain SY095 is an anaerobic mesophilic marine bacterium that was recently isolated from a deep-sea hydrothermal vent on the Southwest Indian Ridge. Here, we present the complete genome sequence of strain SY095. The genome consists of a chromosome of 3,046,753 bp (G + C content of 30.81%) and a plasmid of 36,627 bp (G + C content of 31.29%), encodes 2966 protein, 135 tRNA genes ...
DOI:
10.1016/j.margen.2019.100733

12. Structure analysis of the nucleoprotein of Newcastle disease virus: An insight towards its multimeric form in solution

Author:
Nath, Barnali; Sharma, Kedar; Ahire, Komal; Goyal, Arun; Kumar, Sachin
Source:
International journal of biological macromolecules 2020 v.151 pp. 402-411
ISSN:
0141-8130
Subject:
virion,   etc   ; Avian orthoavulavirus 1; Escherichia coli; RNA; genes; hydrodynamics; image analysis; nucleoproteins; packaging; protein structure; transcription (genetics); viruses;     Show all 12 Subjects
Abstract:
... Newcastle disease virus (NDV) has been explored to a great extent to understand the biology of negative-sense RNA viruses. Nucleoprotein (N) is the most abundant protein in the virus particles, and its primary function is to encapsidate the virus genome for its transcription, replication, and packaging. Here, we report the structural investigations of the N protein of NDV (NDV-N) in solution. The ...
DOI:
10.1016/j.ijbiomac.2020.02.133

13. Differential diagnosis of PRV-infected versus vaccinated pigs using a novel EuNPs-virus antigen probe-based blocking fluorescent lateral flow immunoassay

Author:
Chen, Hui; Zhang, Xiaoli; Jin, Zhiyuan; Huang, Liping; Dan, Hanbing; Xiao, Wei; Liang, Jiajie; Zou, Siyi; Tang, Yong
Source:
Biosensors & bioelectronics 2020 v.155 pp. 112101
ISSN:
0956-5663
Subject:
virion,   etc   ; Suid alphaherpesvirus 1; biosensors; blood serum; cost effectiveness; epitopes; europium; fluorescence; immunoassays; monoclonal antibodies; nanoparticles; swine;     Show all 12 Subjects
Abstract:
... A novel time-resolved fluorescence blocking lateral flow immunoassay (TRF-BLFIA) was developed for on-site differential diagnosis of pseudorabies virus (PRV)-infected and vaccinated pigs using europium nanoparticles (EuNPs)-labeled virion antigens and high titer PRV gE monoclonal antibodies (PRV gE-mAb). Upon application of a positive serum sample, the specific epitopes of gE protein on the EuNPs- ...
DOI:
10.1016/j.bios.2020.112101

14. Virus Bioresistor (VBR) for Detection of Bladder Cancer Marker DJ-1 in Urine at 10 pM in One Minute

Author:
Bhasin, Apurva; Sanders, Emily C.; Ziegler, Joshua M.; Briggs, Jeffrey S.; Drago, Nicholas P.; Attar, Aisha M.; Santos, Alicia M.; True, Marie Y.; Ogata, Alana F.; Yoon, Debora V.; Majumdar, Sudipta; Wheat, Andrew J.; Patterson, Shae V.; Weiss, Gregory A.; Penner, Reginald M.
Source:
Analytical chemistry 2020 v.92 no.9 pp. 6654-6666
ISSN:
1520-6882
Subject:
virion,   etc   ; biosensors; detection limit; electric impedance; electrodes; electroplating; gold; people; polymers; sulfonates; urinary bladder neoplasms; urine; viruses;     Show all 13 Subjects
Abstract:
... DJ-1, a 20.7 kDa protein, is overexpressed in people who have bladder cancer (BC). Its elevated concentration in urine allows it to serve as a marker for BC. However, no biosensor for the detection of DJ-1 has been demonstrated. Here, we describe a virus bioresistor (VBR) capable of detecting DJ-1 in urine at a concentration of 10 pM in 1 min. The VBR consists of a pair of millimeter-scale gold el ...
DOI:
10.1021/acs.analchem.0c00534

15. Viral RNA structure analysis using DMS-MaPseq

Author:
Tomezsko, Phillip; Swaminathan, Harish; Rouskin, Silvi
Source:
Methods 2020
ISSN:
1046-2023
Subject:
virion,   etc   ; DNA viruses; Human immunodeficiency virus 1; RNA; RNA viruses; dimethyl sulfate; gene expression; high-throughput nucleotide sequencing;     Show all 8 Subjects
Abstract:
... RNA structure is critically important to RNA viruses in every part of the replication cycle. RNA structure is also utilized by DNA viruses in order to regulate gene expression and interact with host factors. Advances in next-generation sequencing have greatly enhanced the utility of chemical probing in order to analyze RNA structure. This review will cover some recent viral RNA structural studies ...
DOI:
10.1016/j.ymeth.2020.04.001

16. A Phase 2/3 double blinded, randomized, placebo-controlled study in healthy adult participants in Vietnam to examine the safety and immunogenicity of an inactivated whole virion, alum adjuvanted, A(H5N1) influenza vaccine (IVACFLU-A/H5N1)

Author:
Duong, Tran Nhu; Thiem, Vu Dinh; Anh, Dang Duc; Cuong, Nguyen Phu; Thang, Tran Cong; Huong, Vu Minh; Chien, Vien Chinh; Phuong, Nguyen Thi Lan; Montomoli, Emanuele; Holt, Renee; Scorza, Francesco Berlanda; Flores, Jorge; Tewari, Tushar
Source:
Vaccine 2020 v.38 no.6 pp. 1541-1550
ISSN:
0264-410X
Subject:
virion,   etc   ; adults; alum; avian influenza; hemagglutination; hemolysis; immunogenicity; income; influenza vaccines; injection site; manufacturing; pain; pandemic; seroconversion; Vietnam;     Show all 15 Subjects
Abstract:
... A global shortfall of vaccines for avian influenza A(H5N1) would occur, especially in low- and-middle income countries, if a pandemic were to occur. To address this issue, development of a pre-pandemic influenza vaccine was initiated in 2012, leveraging a recently established influenza vaccine manufacturing capacity in Vietnam.This was a Phase 2/3, double-blinded, randomized, placebo-controlled st ...
DOI:
10.1016/j.vaccine.2019.11.059

17. Structural characterization and antiviral activity of two fucoidans from the brown algae Sargassum henslowianum

Author:
Sun, Qi-Li; Li, Yi; Ni, Long-Quan; Li, Yi-Xuan; Cui, Yong-Sheng; Jiang, Si-Liang; Xie, En-Yi; Du, Juan; Deng, Fei; Dong, Cai-Xia
Source:
Carbohydrate polymers 2020 v.229 pp. 115487
ISSN:
0144-8617
Subject:
virion,   etc   ; Sargassum; adsorption; antiviral properties; fucose; galactose; gel chromatography; inhibitory concentration 50; ion exchange; molecular weight; sulfates;     Show all 11 Subjects
Abstract:
... Purified fucoidans SHAP-1 and SHAP-2 with apparent molecular weights of 6.55 × 105 and 5.89 × 105, respectively, were isolated from Sargassum henslowianum by ion-exchange and gel-filtration column chromatography. They are both composed of fucose and galactose at a ratio of around 3:1 and 31.9% sulfate. The backbone of two fucoidans consists of α-(1→3)-linked L-Fucp residues which are mainly sulfat ...
DOI:
10.1016/j.carbpol.2019.115487

18. Efficient affinity-tagging of M13 phage capsid protein IX for immobilization of protein III-displayed oligopeptide probes on abiotic platforms

Author:
Tong, Zhou; Silo-Suh, Laura A.; Kalalah, Anwar; Dawson, Paul; Chin, Bryan A.; Suh, Sang-Jin
Source:
Applied microbiology and biotechnology 2020 v.104 no.3 pp. 1201-1209
ISSN:
0175-7598
Subject:
virion,   etc   ; Escherichia coli; alleles; bacteriophages; coat proteins; genetic complementation; genetic engineering; ligands; oligopeptides; plasmids; signal peptide; tetracycline;     Show all 12 Subjects
Abstract:
... We developed a genetic approach to efficiently add an affinity tag to every copy of protein IX (pIX) of M13 filamentous bacteriophage in a population. Affinity-tagged phages can be immobilized on a surface in a uniform monolayer in order to position the pIII–displayed peptides or proteins for optimal interaction with ligands. The tagging consists of two major steps. First, gene IX (gIX) of M13 pha ...
DOI:
10.1007/s00253-019-10338-8

19. Lady’s Slipper Orchid and Hydrangea: New Ornamental Hosts of Tobacco Rattle Virus (TRV) in Minnesota

Author:
Baumann, Mattie M.; Kiambi, Roy G.; Lockhart, Benham E.
Source:
Plant health progress 2020 v.21 no.1 pp. 19-20
ISSN:
1535-1025
Subject:
virion,   etc   ; Cypripedium reginae; Hydrangea arborescens; Tobacco rattle virus; flowers; gardens; host range; shrubs; trees; vegetables; viruses; weed hosts; Minnesota;     Show all 13 Subjects
Abstract:
... The lady’s slipper orchids are a subfamily encompassing over 160 species, including the state flower of Minnesota, Cypripedium reginae. Hydrangea is a genus of about 75 species of shrubs and trees that are popular in perennial gardens. Chlorotic and necrotic foliar symptoms were observed in lady’s slipper orchid and Hydrangea arborescens on plants in St. Paul, Minnesota. From partially purified ex ...
DOI:
10.1094/PHP-05-19-0034-BR

20. Role of egg-laying behavior, virulence and local adaptation in a parasitoid’s chances of reproducing in a new host

Author:
Benoist, R.; Paquet, S.; Decourcelle, F.; Guez, J.; Jeannette, R.; Calatayud, P.-A.; Le Ru, B.; Mougel, F.; Kaiser, L.
Source:
Journal of insect physiology 2020 v.120 pp. 103987
ISSN:
0022-1910
Subject:
virion,   etc   ; Cotesia; DNA; Sesamia nonagrioides; biological control; eggs; females; hosts; insect physiology; moths; oviposition; parasitoids; progeny; virulence; viruses; France;     Show all 16 Subjects
Abstract:
... Understanding the ability of parasitoid insects to succeed in new host populations is a relevant question for biological control and adaptive mechanisms. Cotesia typhae is an African parasitoid specialized on the moth Sesamiae nonagrioides, also called the Mediterranean corn borer. Two Kenyan strains of C. typhae differ in their virulence against a new host population from France. We explored beha ...
DOI:
10.1016/j.jinsphys.2019.103987