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1. RNA Packaging in HIV

Author:
Rein, Alan
Source:
Trends in microbiology 2019 v.27 no.8 pp. 715-723
ISSN:
0966-842X
Subject:
virion,   etc   ; Human immunodeficiency virus; RNA packaging; dimerization; genomics; messenger RNA;     Show all 6 Subjects
Abstract:
... Successful replication of the AIDS retrovirus, HIV, requires that its genomic RNA be packaged in assembling virus particles with high fidelity. However, cellular mRNAs can also be packaged under some conditions. Viral RNA (vRNA) contains a ‘packaging signal’ (ψ) and is packaged as a dimer, with two vRNA monomers joined by a limited number of base pairs. It has two conformers, only one of which is ...
DOI:
10.1016/j.tim.2019.04.003

2. The evolution of collective infectious units in viruses

Author:
Leeks, Asher; Sanjuán, Rafael; West, Stuart A.
Source:
Virus research 2019 v.265 pp. 94-101
ISSN:
0168-1702
Subject:
virion,   etc   ; evolution; genome; hosts; models; packaging; pathogenesis; virus replication; viruses;     Show all 9 Subjects
Abstract:
... Viruses frequently spread among cells or hosts in groups, with multiple viral genomes inside the same infectious unit. These collective infectious units can consist of multiple viral genomes inside the same virion, or multiple virions inside a larger structure such as a vesicle. Collective infectious units deliver multiple viral genomes to the same cell simultaneously, which can have important imp ...
DOI:
10.1016/j.virusres.2019.03.013

3. Herpesvirus tegument and immediate early proteins are pioneers in the battle between viral infection and nuclear domain 10-related host defense

Author:
Zhang, Kuan; van Drunen Littel-van den Hurk, Sylvia
Source:
Virus research 2017 v.238 pp. 40-48
ISSN:
0168-1702
Subject:
virion,   etc   ; genome; proteins; viruses;     Show all 4 Subjects
Abstract:
... The sophisticated anti-viral functions of nuclear domain 10 (ND10) are revealed by identifying the role of each component and the countermeasures applied by viruses. Several ND10 proteins suppress herpesviruses at initial and early phases of infection. Herpesviruses need to antagonize these anti-viral proteins to start a productive infection. In this review the recently identified similarities and ...
DOI:
10.1016/j.virusres.2017.05.023

4. Bacteriophage imaging: past, present and future

Author:
Almeida, Gabriel MF.; Leppänen, Miika; Maasilta, Ilari J.; Sundberg, Lotta-Riina
Source:
Research in microbiology 2018 v.169 no.9 pp. 488-494
ISSN:
0923-2508
Subject:
virion,   etc   ; bacteriophages; biosphere; hosts; image analysis; technology;     Show all 6 Subjects
Abstract:
... The visualization of viral particles only became possible after the advent of the electron microscope. The first bacteriophage images were published in 1940 and were soon followed by many other publications that helped to elucidate the structure of the particles and their interaction with the bacterial hosts. As sample preparation improved and new technologies were developed, phage imaging became ...
DOI:
10.1016/j.resmic.2018.05.006

5. Recent trends in click chemistry as a promising technology for virus-related research

Author:
Ouyang, Ting; Liu, Xiaohui; Ouyang, Hongsheng; Ren, Linzhu
Source:
Virus research 2018 v.256 pp. 21-28
ISSN:
0168-1702
Subject:
virion,   etc   ; antiviral agents; nucleic acids; organic chemistry;     Show all 4 Subjects
Abstract:
... Click chemistry involves reactions that were originally introduced and used in organic chemistry to generate substances by joining small units together with heteroatom linkages (C-X-C). Over the last few decades, click chemistry has been widely used in virus-related research. Using click chemistry, the virus particle as well as viral protein and nucleic acids can be labeled. Subsequently, the labe ...
DOI:
10.1016/j.virusres.2018.08.003

6. Self-assembled supramolecular systems for bone engineering applications

Author:
Pan, Panpan; Chen, Xiao; Metavarayuth, Kamolrat; Su, Jiacan; Wang, Qian
Source:
Current opinion in colloid & interface science 2018 v.35 pp. 104-111
ISSN:
1359-0294
Subject:
virion,   etc   ; bone formation; bones; resorption; tissue engineering;     Show all 5 Subjects
Abstract:
... Bone regeneration is a complicated physiological process comprising of bone formation and resorption under the circumstances of some pathological conditions. This review highlights the recent development of self-assembled supramolecular systems, including spontaneous collagen-based scaffold, self-assembled peptide-based materials, modified cyclodextrin-based materials, and assembled protein or vir ...
DOI:
10.1016/j.cocis.2018.01.015

7. The Golgi sorting motifs of human cytomegalovirus UL138 are not required for latency maintenance

Author:
Gelbmann, Christopher B.; Kalejta, Robert F.
Source:
Virus research 2019 v.270 pp. 197646
ISSN:
0168-1702
Subject:
virion,   etc   ; Human betaherpesvirus 5; gene expression; gene expression regulation; models; mutants; progeny; protein transport; transcription (genetics);     Show all 9 Subjects
Abstract:
... Human cytomegalovirus (HCMV) establishes latency within incompletely differentiated cells of the myeloid lineage. The viral protein UL138 participates in establishing and maintaining this latent state. UL138 has multiple functions during latency that include silencing productive phase viral gene transcription and modulating intracellular protein trafficking. Trafficking and subsequent downregulati ...
DOI:
10.1016/j.virusres.2019.197646

8. AcMNPV-miR-3 is a miRNA encoded by Autographa californica nucleopolyhedrovirus and regulates the viral infection by targeting ac101

Author:
Jiao, Yingzhen; Wang, Jinwen; Deng, Riqiang; Yu, Xinghua; Wang, Xunzhang
Source:
Virus research 2019 v.267 pp. 49-58
ISSN:
0168-1702
Subject:
virion,   etc   ; Autographa californica; Autographa californica multiple nucleopolyhedrovirus; genes; microRNA; non-coding RNA;     Show all 6 Subjects
Abstract:
... MicroRNAs (miRNAs), which are small noncoding RNAs found in plants, animals, and many viruses, regulate various biological processes. Our group has previously reported the first miRNA encoded by Autographa californica multiple Nucleopolyhedrovirus (AcMNPV), AcMNPV-miR-1, which regulates the expression of three viral genes. This study characterizes another miRNA encoded by AcMNPV, AcMNPV-miR-3. Thi ...
DOI:
10.1016/j.virusres.2019.05.004

9. Potency test to discriminate between differentially over-inactivated rabies vaccines: Agreement between the NIH assay and a G-protein based ELISA

Author:
Toinon, Audrey; Moreno, Nadege; Chausse, Heloise; Mas, Emilie; Nicolai, Marie Claire; Guinchard, Fabien; Jaudinaud, Isabelle; Guinet-Morlot, Françoise; Riou, Patrice; Manin, Catherine
Source:
Biologicals 2019 v.60 pp. 49-54
ISSN:
1045-1056
Subject:
virion,   etc   ; G-proteins; analytical methods; enzyme-linked immunosorbent assay; immunization; mice; rabies; vaccines;     Show all 8 Subjects
Abstract:
... The NIH assay is used to assess the potency of rabies vaccine and is currently a key measure required for vaccine release. As this test involves immunization of mice and subsequent viral challenge, efforts are being made to develop alternative analytical methods that do not rely on animal testing. Sanofi Pasteur has reported the development of a G-protein specific ELISA assay that has shown agreem ...
DOI:
10.1016/j.biologicals.2019.05.004

10. Adenovirus behavior in air handling unit fiberglass filters

Author:
Bandaly, Victor; Joubert, Aurélie; Andres, Yves; Le Cann, Pierre
Source:
Aerobiologia 2019 v.35 no.2 pp. 357-366
ISSN:
0393-5965
Subject:
virion,   etc   ; Adenoviridae; DNA; aerosols; air; atomization; buildings; fiberglass; filters; pathogenicity; proteins; ventilation systems; viral contamination; viruses;     Show all 14 Subjects
Abstract:
... Viral aerosols can lead to respiratory viral infections with high infectivity. About 90% of people’s time is spent in closed environments. A few studies have pointed out that the ventilation systems in air handling units (AHUs) that treat and transmit a new synthetic clean and conditioned environment can also spread and transport viral particles in buildings. The aim of this work is to study the c ...
DOI:
10.1007/s10453-019-09565-3

11. Cyanophage MazG is a pyrophosphohydrolase but unable to hydrolyse magic spot nucleotides

Author:
Rihtman, Branko; Bowman‐Grahl, Sabine; Millard, Andrew; Corrigan, Rebecca M.; Clokie, Martha R. J.; Scanlan, David J.
Source:
Environmental microbiology reports 2019 v.11 no.3 pp. 448-455
ISSN:
1758-2229
Subject:
virion,   etc   ; Synechococcus; bacteriophages; cyanophages; enzyme activity; genes; hydrolysis; nucleotides; progeny; proteins; pyrophosphatases; stress response;     Show all 12 Subjects
Abstract:
... Bacteriophage possess a variety of auxiliary metabolic genes of bacterial origin. These proteins enable them to maximize infection efficiency, subverting bacterial metabolic processes for the purpose of viral genome replication and synthesis of the next generation of virion progeny. Here, we examined the enzymatic activity of a cyanophage MazG protein – a putative pyrophosphohydrolase previously i ...
DOI:
10.1111/1758-2229.12741

12. The utility of flow cytometry for potable reuse

Author:
Rockey, Nicole; Bischel, Heather N; Kohn, Tamar; Pecson, Brian; Wigginton, Krista R
Source:
Current opinion in biotechnology 2019 v.57 pp. 42-49
ISSN:
0958-1669
Subject:
virion,   etc   ; Protozoa; bacteria; drinking water; flow cytometry; monitoring; pathogens; public health; viruses; wastewater treatment; water reuse;     Show all 11 Subjects
Abstract:
... Protecting public health from pathogens is critical when treating wastewater to drinking water standards (i.e., planned water reuse). Viruses are a principal concern, yet real-time monitoring strategies do not currently measure virus removal through reuse processes. Flow cytometry (FCM) has enabled rapid and sensitive bacteria monitoring in water treatment applications, but methods for virus and p ...
DOI:
10.1016/j.copbio.2018.12.009

13. Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B

Author:
Zhao, Xin; Zhang, Guigen; Liu, Sheng; Chen, Xiangpeng; Peng, Ruchao; Dai, Lianpan; Qu, Xiao; Li, Shihua; Song, Hao; Gao, Zhengrong; Yuan, Pengfei; Liu, Zhiheng; Li, Changyao; Shang, Zifang; Li, Yan; Zhang, Meifan; Qi, Jianxun; Wang, Han; Du, Ning; Wu, Yan; Bi, Yuhai; Gao, Shan; Shi, Yi; Yan, Jinghua; Zhang, Yong; Xie, Zhengde; Wei, Wensheng; Gao, George F.
Source:
Cell 2019 v.177 no.6 pp. 1553-1565.e16
ISSN:
0092-8674
Subject:
virion,   etc   ; Enterovirus B; cryo-electron microscopy; etiological agents; humans; infectious diseases; receptors; viruses;     Show all 8 Subjects
Abstract:
... Enterovirus B (EV-B), a major proportion of the genus Enterovirus in the family Picornaviridae, is the causative agent of severe human infectious diseases. Although cellular receptors for coxsackievirus B in EV-B have been identified, receptors mediating virus entry, especially the uncoating process of echovirus and other EV-B remain obscure. Here, we found that human neonatal Fc receptor (FcRn) i ...
DOI:
10.1016/j.cell.2019.04.035

14. Divalent oseltamivir analogues as potent influenza neuraminidase inhibitors

Author:
Yan, Zhong-Li; Liu, Ao-Yun; Wei, Xia-Xia; Zhang, Zhuang; Qin, Long; Yu, Qun; Yu, Peng; Lu, Kui; Yang, Yang
Source:
Carbohydrate research 2019 v.477 pp. 32-38
ISSN:
0008-6215
Subject:
virion,   etc   ; Orthomyxoviridae; carbohydrates; enzyme inhibitors; esterification; influenza; oseltamivir; sialidase; structure-activity relationships; viruses;     Show all 10 Subjects
Abstract:
... A panel of divalent oseltamivir and guanidino oseltamivir analogues with esterification on the carboxyl acid group as potent inhibitors of influenza virus neuraminidase was prepared via click reaction. The primary structure activity relationship study demonstrated that appropriate distance between two oseltamivir monomers around 30 Å can crosslink two adjacent neuraminidase tetramers on the virion ...
DOI:
10.1016/j.carres.2019.03.012

15. Endoplasmic reticulum remodeling induced by Wheat yellow mosaic virus infection studied by transmission electron microscopy

Author:
Xie, Li; Song, Xi-jiao; Liao, Zhen-feng; Wu, Bin; Yang, Jian; Zhang, Hengmu; Hong, Jian
Source:
Micron 2019 v.120 pp. 80-90
ISSN:
0968-4328
Subject:
virion,   etc   ; Wheat yellow mosaic virus; antibodies; endoplasmic reticulum; tomography; transmission electron microscopy;     Show all 6 Subjects
Abstract:
... Plant virus was a kind of organism lived depending on infecting viable host cell and propagated their posterity by replicating its hereditary nucleotide, transcripting into protein, assembling protein and nucleotide into virion (Ortín and Parra, 2006; Sanfaçon, 2005). Viral infection usually induces remodeling of host cell, especially endoplasmic reticulum (ER) for generating membrane packed viral ...
DOI:
10.1016/j.micron.2019.01.007

16. Extracellular vesicles: Vehicles of en bloc viral transmission

Author:
Altan-Bonnet, Nihal; Perales, Celia; Domingo, Esteban
Source:
Virus research 2019 v.265 pp. 143-149
ISSN:
0168-1702
Subject:
virion,   etc   ; DNA viruses; RNA; RNA viruses; genome; hosts; mutagenesis; mutants; virulence; virus transmission; viruses;     Show all 11 Subjects
Abstract:
... En Bloc transmission of viruses allow multiple genomes to collectivelly penetrate and initiate infection in the same cell, often resulting in enhanced infectivity. Given the quasispecies (mutant cloud) nature of RNA viruses and many DNA viruses, en bloc transmission of multiple genomes provides different starting points in sequence space to initiate adaptive walks, and has implications for modulat ...
DOI:
10.1016/j.virusres.2019.03.023

17. The study of the phiKZ phage non-canonical non-virion RNA polymerase

Author:
Orekhova, Mariia; Koreshova, Alevtina; Artamonova, Tatyana; Khodorkovskii, Mikhail; Yakunina, Maria
Source:
Biochemical and biophysical research communications 2019 v.511 no.4 pp. 759-764
ISSN:
0006-291X
Subject:
virion,   etc   ; Archaea; DNA; DNA-directed RNA polymerase; RNA; bacteria; bacteriophages; eukaryotic cells; protein subunits;     Show all 9 Subjects
Abstract:
... Non-canonical multisubunit DNA-dependent RNA-polymerases (RNAP) form a new group of the main transcription enzymes, which have only distinct homology to the catalytic subunits of canonical RNAPs of bacteria, archaea and eukaryotes. One of the rare non-canonical RNAP, which was partially biochemically characterized, is non-virion RNAP (nvRNAP) encoded by Pseudomonas phage phiKZ. PhiKZ nvRNAP consis ...
DOI:
10.1016/j.bbrc.2019.02.132

18. Benzoxazine monomer derived carbon dots as a broad-spectrum agent to block viral infectivity

Author:
Huang, Shaomei; Gu, Jiangjiang; Ye, Jing; Fang, Bin; Wan, Shengfeng; Wang, Caoyu; Ashraf, Usama; Li, Qi; Wang, Xugang; Shao, Lin; Song, Yunfeng; Zheng, Xinsheng; Cao, Feifei; Cao, Shengbo
Source:
Journal of colloid and interface science 2019 v.542 pp. 198-206
ISSN:
0021-9797
Subject:
virion,   etc   ; Flaviviridae; Ungulate protoparvovirus 1; antiviral agents; carbon quantum dots; death; encephalitis; pathogenicity; viruses;     Show all 9 Subjects
Abstract:
... Multiple viruses can cause infection and death of millions annually. Of these, flaviviruses are found to be highly prevalent in recent years with no distinctive antiviral therapies. Therefore, there is a desperate need for broad-spectrum antiviral drugs that can be active against a large number of existing and emerging viruses. Herein, we prepared a kind of benzoxazine monomer derived carbon dots ...
DOI:
10.1016/j.jcis.2019.02.010

19. Evidence for an ichnovirus machinery in parasitoids of coleopteran larvae

Author:
Robin, Stéphanie; Ravallec, Marc; Frayssinet, Marie; Whitfield, James; Jouan, Véronique; Legeai, Fabrice; Volkoff, Anne-Nathalie
Source:
Virus research 2019 v.263 pp. 189-206
ISSN:
0168-1702
Subject:
virion,   etc   ; Bathyplectes anurus; Hypera postica; Ichnovirus; genes; larvae; messenger RNA; parasitoids; transcriptome;     Show all 9 Subjects
Abstract:
... Bathyplectes spp. are ichneumonid solitary larval parasitoids of the alfalfa weevil which have been classified in the subfamily Campopleginae and which harbor atypical virus particles. Despite the morphological differences between Bathyplectes spp. particles and the polydnaviruses carried by a number of related campoplegine species, called ichnoviruses, the process by which they are produced is ve ...
DOI:
10.1016/j.virusres.2019.02.001

20. Micropatterned Viral Membrane Clusters for Antiviral Drug Evaluation

Author:
Park, Soohyun; Jackman, Joshua A.; Xu, Xiaobin; Weiss, Paul S.; Cho, Nam-Joon
Source:
ACS applied materials & interfaces 2019 v.11 no.15 pp. 13984-13990
ISSN:
1944-8252
Subject:
virion,   etc   ; antiviral agents; biomimetics; drug evaluation; encapsulation; fluorescence; geometry; nanoparticles; peptides;     Show all 9 Subjects
Abstract:
... The function of biological nanoparticles, such as membrane-enveloped viral particles, is often enhanced when the particles form higher-order supramolecular assemblies. While there is intense interest in developing biomimetic platforms that recapitulate these collective properties, existing platforms are limited to mimicking individual virus particles. Here, we present a micropatterning strategy to ...
DOI:
10.1021/acsami.9b01724