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You searched for: Subject "virus replication" Remove constraint Subject: "virus replication"
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1. Modulation of Zika virus replication via glycosphingolipids

Author:
Kouacou V. Konan; Simon Alem Ogbamikael; Eric Yager; Toshiyuki Yamaji; Jennifer Cerone; Meredith Monaco-Brown; Margarida Barroso; Kentaro Hanada
Source:
Virology 2022 v.572 pp. 17-27
ISSN:
0042-6822
Subject:
virus replication,   etc   ; Zika virus; glucosylceramides; viruses;     Show all 4 Subjects
Abstract:
... The enveloped positive-sense RNA viruses including Zika virus (ZIKV) need host lipids to successfully replicate. The nature of the lipids and the replication step(s) where lipids are utilized often vary amongst viruses. In this study, we demonstrate that ZIKV particle envelope is significantly enriched in distinct sphingolipid species. To determine the role of sphingolipids in ZIKV replication, we ...
DOI:
10.1016/j.virol.2022.03.014

2. Cellular Lipids—Hijacked Victims of Viruses

Author:
Bozena Omasta; Jana Tomaskova
Source:
Viruses 2022 v.14 no.9 pp. -
ISSN:
1999-4915
Subject:
virus replication,   etc   ; coevolution; lipid composition; lipids; organelles;     Show all 5 Subjects
Abstract:
... Over the millions of years-long co-evolution with their hosts, viruses have evolved plenty of mechanisms through which they are able to escape cellular anti-viral defenses and utilize cellular pathways and organelles for replication and production of infectious virions. In recent years, it has become clear that lipids play an important role during viral replication. Viruses use cellular lipids in ...
DOI:
10.3390/v14091896

3. Triplex digital PCR assays for the quantification of intact proviral HIV-1 DNA

Author:
Willem van Snippenberg; David Gleerup; Sofie Rutsaert; Linos Vandekerckhove; Ward De Spiegelaere; Wim Trypsteen
Source:
Methods 2022 v.201 pp. 41-48
ISSN:
1046-2023
Subject:
virus replication,   etc   ; DNA; color; models; patients; proviruses;     Show all 6 Subjects
Abstract:
... The development of an HIV-1 cure is hampered by the existence of a persistent (latent) reservoir that contains a small proportion of replication-competent intact proviruses which refuels viral replication upon treatment discontinuation. Therefore, an accurate evaluation and quantification of these (intact) proviruses is essential to determine the efficacy of HIV-1 cure strategies which aim to elim ...
DOI:
10.1016/j.ymeth.2021.05.006

4. The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1

Author:
Andreja Zubković; Ines Žarak; Ivana Ratkaj; Filip Rokić; Maja Jekić; Marina Pribanić Matešić; Ricardo Lebrón; Cristina Gómez-Martín; Berislav Lisnić; Vanda Juranić Lisnić; Stipan Jonjić; Dongli Pan; Oliver Vugrek; Michael Hackenberg; Igor Jurak
Source:
Viruses 2022 v.14 no.8 pp. -
ISSN:
1999-4915
Subject:
virus replication,   etc   ; Human alphaherpesvirus 1; microRNA; viruses;     Show all 4 Subjects
Abstract:
... Herpes simplex virus 1 (HSV-1) expresses a large number of miRNAs, and their function is still not completely understood. In addition, HSV-1 has been found to deregulate host miRNAs, which adds to the complexity of the regulation of efficient virus replication. In this study, we comprehensively addressed the deregulation of host miRNAs by massive-parallel sequencing. We found that only miRNAs expr ...
DOI:
10.3390/v14081661

5. Full-length MAVS, a mitochondrial antiviral-signaling protein, inhibits hepatitis E virus replication, requiring JAK-STAT signaling

Author:
Changbo Qu; Yang Li; Yunlong Li; Yihang Pan
Source:
Archives of virology 2022 v.167 no.5 pp. 1293-1300
ISSN:
0304-8608
Subject:
virus replication,   etc   ; Orthohepevirus A; immunity; interferons; mitochondria;     Show all 5 Subjects
Abstract:
... Hepatitis E virus (HEV) infection is the leading cause of acute hepatitis worldwide. The mitochondrial antiviral signaling protein (MAVS)-mediated interferon (IFN) response plays a pivotal role in hepatic antiviral immunity. However, little is known about the effect of overexpression of MAVS on HEV infection. Full-length MAVS (FL-MAVS) is the main form of MAVS that increases the production of IFNs ...
DOI:
10.1007/s00705-022-05415-9

6. SP1/miR-92a-1–5p/SOCS5: A novel regulatory axis in feline panleukopenia virus replication

Author:
Ruiying Liang; Lin Liang; Jingjie Zhao; Weiquan Liu; Shangjin Cui; Xinglin Zhang; Lingling Zhang
Source:
Veterinary microbiology 2022 v.273 pp. 109549
ISSN:
0378-1135
Subject:
virus replication,   etc   ; Carnivore protoparvovirus 1; cytokines; interferons; microRNA;     Show all 5 Subjects
Abstract:
... MicroRNAs (miRNAs) are vital post-transcriptional regulators that participate in host-pathogen interactions by modulating the expression of cellular factors. Previous studies have demonstrated that feline panleukopenia virus (FPV) alters miRNA expression levels within host cells. However, the relationship between FPV replication and host miRNAs remains unclear. Here, we demonstrated that FPV infec ...
DOI:
10.1016/j.vetmic.2022.109549

7. Antiviral Activity and Mechanisms of Seaweeds Bioactive Compounds on Enveloped Viruses—A Review

Author:
Silvia Lomartire; Ana M. M. Gonçalves
Source:
Marine drugs 2022 v.20 no.6 pp. -
ISSN:
1660-3397
Subject:
virus replication,   etc   ; Orthocoronavirinae; antiviral properties; influenza; macroalgae; metabolites;     Show all 6 Subjects
Abstract:
... In the last decades, the interest in seaweed has significantly increased. Bioactive compounds from seaweed’s currently receive major attention from pharmaceutical companies as they express several interesting biological activities which are beneficial for humans. The structural diversity of seaweed metabolites provides diverse biological activities which are expressed through diverse mechanisms of ...
DOI:
10.3390/md20060385

8. Phytosterol metabolism in plant positive-strand RNA virus replication

Author:
Teresa Altabella; Karla Ramirez-Estrada; Albert Ferrer
Source:
Plant cell reports 2022 v.41 no.2 pp. 281-291
ISSN:
0721-7714
Subject:
virus replication,   etc   ; RNA; endomembrane system; phytosterols; viral genome; viruses;     Show all 6 Subjects
Abstract:
... The genome of most plant viruses consists of a single positive-strand of RNA (+ ssRNA). Successful replication of these viruses is fully dependent on the endomembrane system of the infected cells, which experiences a massive proliferation and a profound reshaping that enables assembly of the macromolecular complexes where virus genome replication occurs. Assembly of these viral replicase complexes ...
DOI:
10.1007/s00299-021-02799-x

9. Subcellular dynamics of red clover necrotic mosaic virus double-stranded RNAs in infected plant cells

Author:
Shota Takata; Kazuyuki Mise; Yoshitaka Takano; Masanori Kaido
Source:
Virology 2022 v.568 pp. 126-139
ISSN:
0042-6822
Subject:
virus replication,   etc   ; Red clover necrotic mosaic virus; endoplasmic reticulum;     Show all 3 Subjects
Abstract:
... New evidences are emerging to support the importance of viral replication complexes (VRCs) in not only viral replication, but also viral cell-to-cell movement. Currently, how VRCs grow in size and colocalize with viral movement proteins (MPs) remains unclear. Herein, we performed live-cell imaging of red clover necrotic mosaic virus (RCNMV) dsRNA by using reporter B2-GFP plants. Tiny granules of d ...
DOI:
10.1016/j.virol.2022.01.015

10. Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication

Author:
Jack Chun-Chieh Hsu; Maudry Laurent-Rolle; Joanna B. Pawlak; Hongjie Xia; Amit Kunte; Jia Shee Hee; Jaechul Lim; Lawrence D. Harris; James M. Wood; Gary B. Evans; Pei-Yong Shi; Tyler L. Grove; Steven C. Almo; Peter Cresswell
Source:
Molecular cell 2022 v.82 no.9 pp. 1631-1642.e6
ISSN:
1097-2765
Subject:
virus replication,   etc   ; RNA; innate immunity; methionine; ribosomes; stress response;     Show all 6 Subjects
Abstract:
... Innate immune responses induce hundreds of interferon-stimulated genes (ISGs). Viperin, a member of the radical S-adenosyl methionine (SAM) superfamily of enzymes, is the product of one such ISG that restricts the replication of a broad spectrum of viruses. Here, we report a previously unknown antiviral mechanism in which viperin activates a ribosome collision-dependent pathway that inhibits both ...
DOI:
10.1016/j.molcel.2022.02.031

11. Epstein-Barr virus lytic replication activates and is dependent upon MAPK-interacting kinase 1/2 in a cell-type dependent manner.

Author:
Amy L. Adamson; Dana Jeffus; Alexis Davis; Eva Greengrove
Source:
Virology 2022 v.572 pp. 72-85
ISSN:
0042-6822
Subject:
virus replication,   etc   ; Human gammaherpesvirus 4; epithelium; metastasis; protein synthesis;     Show all 5 Subjects
Abstract:
... Epstein-Barr virus (EBV) is known to manipulate its cellular environment to enhance viral replication, which can lead to dysregulation of cellular machinery, setting the stage for potential future disease. Previous research showed that under rapamycin-mediated inhibition of mTORC1, EBV lytic protein production was altered in a cell-type specific manner, suggesting that EBV differentially activates ...
DOI:
10.1016/j.virol.2022.05.005

12. Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors

Author:
Long Phi Dinh; Jian Sun; Courtney D. Glenn; Krunal Patel; Julie A. Pigza; Matthew G. Donahue; Larry Yet; Jacques J. Kessl
Source:
Viruses 2022 v.14 no.7 pp. -
ISSN:
1999-4915
Subject:
virus replication,   etc   ; active sites; bromine; integrases; mutants; quinolines; viruses;     Show all 7 Subjects
Abstract:
... Allosteric HIV-1 integrase (IN) inhibitors, or ALLINIs, are a new class of antiviral agents that bind at the dimer interface of the IN, away from the enzymatic catalytic site and block viral replication by triggering an aberrant multimerization of the viral enzyme. To further our understanding of the important binding features of multi-substituted quinoline-based ALLINIs, we have examined the IN m ...
DOI:
10.3390/v14071466

13. Analysis of the long noncoding RNA profiles of RD and SH-SY5Y cells infected with coxsackievirus B5, using RNA sequencing

Author:
Peiying Teng; Heng Yang; Jing Li; Fan Yang; Wei Chen
Source:
Archives of virology 2022 v.167 no.2 pp. 367-376
ISSN:
0304-8608
Subject:
virus replication,   etc   ; gene ontology; humans; mouth; non-coding RNA;     Show all 5 Subjects
Abstract:
... Hand, foot, and mouth disease caused by coxsackievirus B5 (CV-B5) is a considerable threat to infant health, especially with regard to neurological damage. Long noncoding RNAs (lncRNAs) are known to play pivotal roles in virus-host interactions. However, the roles of lncRNAs in CV-B5-host interactions have not yet been elucidated. In the current study, we used RNA sequencing to determine the expre ...
DOI:
10.1007/s00705-021-05313-6

14. DDX56 antagonizes IFN-β production to enhance EMCV replication by inhibiting IRF3 nuclear translocation

Author:
Shujuan Xu; Jingying Xie; Xiangbo Zhang; Lei Chen; Yingjie Bi; Xiangrong Li; Adi Idris; Ruofei Feng
Source:
Veterinary microbiology 2022 v.264 pp. 109304
ISSN:
0378-1135
Subject:
virus replication,   etc   ; Cardiovirus A; RNA helicases; innate immunity; phosphorylation;     Show all 5 Subjects
Abstract:
... DEAD (Asp-Glu-Ala-Asp)-box RNA helicases (DDX) play important roles in viral infection, either as cytosolic viral nucleic acids sensors or as essential host factors for viral replication. In this study, we identified DDX56 as a positive regulator for encephalomyocarditis virus (EMCV) replication. EMCV infection promotes DDX56 expression via its viral proteins, VP3 and 3C. We showed that DDX56 over ...
DOI:
10.1016/j.vetmic.2021.109304

15. Impact of the Potential m6A Modification Sites at the 3′UTR of Alfalfa Mosaic Virus RNA3 in the Viral Infection

Author:
Luis Alvarado-Marchena; Mireya Martínez-Pérez; Jesús R. Úbeda; Vicente Pallas; Frederic Aparicio
Source:
Viruses 2022 v.14 no.8 pp. -
ISSN:
1999-4915
Subject:
virus replication,   etc   ; Alfalfa mosaic virus; RNA; adenosine; coat proteins; genome;     Show all 6 Subjects
Abstract:
... We have previously reported the presence of m⁶A in the AMV (Alfamovirus, Bromoviridae) genome. Interestingly, two of these putative m⁶A-sites are in hairpin (hp) structures in the 3’UTR of the viral RNA3. One site (₂₀₁₂AAACU₂₀₁₆) is in the loop of hpB, within the coat protein binding site 1 (CPB1), while the other (₁₉₀₀UGACC₁₉₀₄) is in the lower stem of hpE, a loop previously associated with AMV n ...
DOI:
10.3390/v14081718

16. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains

Author:
Carla Prezioso; Sara Passerini; Dolores Limongi; Anna Teresa Palamara; Ugo Moens; Valeria Pietropaolo
Source:
Viruses 2022 v.14 no.9 pp. -
ISSN:
1999-4915
Subject:
virus replication,   etc   ; DNA; Polyomaviridae; exosomes; microRNA; transcription (genetics); viral load;     Show all 7 Subjects
Abstract:
... Since the non-coding control region (NCCR) and microRNA (miRNA) could represent two different and independent modalities of regulating JC polyomavirus (JCPyV) replication at the transcriptional and post-transcriptional levels, the interplay between JC viral load based on NCCR architecture and miRNA levels, following JCPyV infection with archetypal and rearranged (rr)-NCCR JCPyV variants, was explo ...
DOI:
10.3390/v14092070

17. The Reversible Methylation of m6A Is Involved in Plant Virus Infection

Author:
Jianying Yue; Yao Wei; Mingmin Zhao
Source:
Biology 2022 v.11 no.2 pp. -
ISSN:
2079-7737
Subject:
virus replication,   etc   ; RNA; humans; immune response; methylation; viral genome; viruses;     Show all 7 Subjects
Abstract:
... In recent years, m6A RNA methylation has attracted broad interest and is becoming a hot research topic. It has been demonstrated that there is a strong association between m6A and viral infection in the human system. The life cycles of plant RNA viruses are often coordinated with the mechanisms of their RNA modification. Here, we reviewed recent advances in m6A methylation in plant viruses. It app ...
DOI:
10.3390/biology11020271

18. Fish Innate Immune Response to Viral Infection—An Overview of Five Major Antiviral Genes

Author:
Maria del Mar Ortega-Villaizan; Veronica Chico; Luis Perez
Source:
Viruses 2022 v.14 no.7 pp. -
ISSN:
1999-4915
Subject:
virus replication,   etc   ; DNA; aquaculture industry; cell culture; fish; innate immunity; pathogenesis;     Show all 7 Subjects
Abstract:
... Fish viral diseases represent a constant threat to aquaculture production. Thus, a better understanding of the cellular mechanisms involved in establishing an antiviral state associated with protection against virus replication and pathogenesis is paramount for a sustainable aquaculture industry. This review summarizes the current state of knowledge on five selected host innate immune-related gene ...
DOI:
10.3390/v14071546

19. Bovine Herpesvirus-1 Glycoprotein M Mediates the Translocation to the Golgi Apparatus and Packaging of VP8

Author:
Soumya Sucharita; Suresh Tikoo; Sylvia van Drunen Littel-van den Hurk
Source:
Viruses 2022 v.14 no.9 pp. -
ISSN:
1999-4915
Subject:
virus replication,   etc   ; Bovine alphaherpesvirus 1; Golgi apparatus; glycoproteins; mutants; plasmids; viruses;     Show all 7 Subjects
Abstract:
... VP8, the most abundant tegument protein of bovine herpesvirus-1 (BoHV-1), plays an important role in viral replication. According to our previous studies, VP8 localizes to the Golgi apparatus of BoHV-1-infected cells where it can be packaged into the virus; however, Golgi localization of VP8 does not occur outside of the context of infection. The goal of this study was to identify the viral factor ...
DOI:
10.3390/v14091985

20. Characterization of the Cross-Species Transmission Potential for Porcine Deltacoronaviruses Expressing Sparrow Coronavirus Spike Protein in Commercial Poultry

Author:
Moyasar A. Alhamo; Patricia A. Boley; Mingde Liu; Xiaoyu Niu; Kush Kumar Yadav; Carolyn Lee; Linda J. Saif; Qiuhong Wang; Scott P. Kenney
Source:
Viruses 2022 v.14 no.6 pp. -
ISSN:
1999-4915
Subject:
virus replication,   etc   ; Passeriformes; Porcine deltacoronaviruses; chickens; genomics; mortality; pathogenesis; swine; viruses;     Show all 9 Subjects
Abstract:
... Avian species often serve as transmission vectors and sources of recombination for viral infections due to their ability to travel vast distances and their gregarious behaviors. Recently a novel deltacoronavirus (DCoV) was identified in sparrows. Sparrow deltacoronavirus (SpDCoV), coupled with close contact between sparrows and swine carrying porcine deltacoronavirus (PDCoV) may facilitate recombi ...
DOI:
10.3390/v14061225