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1. How pesticides affect neonates? - Exposure, health implications and determination of metabolites

Author:
María José Santoyo Treviño; Marina Pereira-Coelho; Andrea Guadalupe Rodríguez López; Sergio Zarazúa; Luiz Augusto dos Santos Madureira; Tomasz Majchrzak; Justyna Płotka-Wasylka
Source:
Science of the total environment 2023 v.856 pp. 158859
ISSN:
0048-9697
Subject:
xenobiotics,   etc   ; breast milk; child health; children; environment; environmental exposure; metabolism; metabolites; toxic substances; toxicity; urine;     Show all 11 Subjects
Abstract:
... This review covers key information related to the effects of pesticides on fetal and child health. All humans are exposed to environmental toxicants, however child's health, due to their high vulnerability, should be of special concern. They are continuously exposed to environmental xenobiotics including a wide variety of pesticides, and other pollutants. These compounds can enter the child's body ...
DOI:
10.1016/j.scitotenv.2022.158859

2. The plastisphere of biodegradable and conventional microplastics from residues exhibit distinct microbial structure, network and function in plastic-mulching farmland

Author:
Kang Li; Weiqian Jia; Libo Xu; Mengjun Zhang; Yi Huang
Source:
Journal of hazardous materials 2023 v.442 pp. 130011
ISSN:
0304-3894
Subject:
xenobiotics,   etc   ; Actinobacteria; Proteobacteria; agricultural land; amino acid metabolism; biodegradability; biodegradation; carbohydrate metabolism; carbon; humans; microplastics; nitrogen; soil; statistical analysis; China;     Show all 15 Subjects
Abstract:
... The inhomogeneity of plastisphere and soil may result in different microbial communities, thus potentially affecting soil functions. Biodegradable plastics offer an alternative to conventional plastics, nevertheless, the inadequate end-of-life treatment of biodegradable plastics may release more microplastics. Herein, we collected PE and PBAT/PLA microplastics in plastic-mulching farmland in Hebei ...
DOI:
10.1016/j.jhazmat.2022.130011

3. Polyethylene mulching film degrading bacteria within the plastisphere: Co-culture of plastic degrading strains screened by bacterial community succession

Author:
Peiyuan Wang; Jiaxi Liu; Siqi Han; Yufan Wang; Yifan Duan; Tingting Liu; Lijun Hou; Zengqiang Zhang; Li Li; Yanbing Lin
Source:
Journal of hazardous materials 2023 v.442 pp. 130045
ISSN:
0304-3894
Subject:
xenobiotics,   etc   ; Bacillus aryabhattai; Microbacterium; Rhodanobacter; Rhodopseudomonas; adhesion; agricultural land; bacterial communities; bacterial growth; biodegradation; biofilm; coculture; community structure; metabolism; niches; pollution; polyethylene; prediction; species diversity;     Show all 19 Subjects
Abstract:
... As an ecological niche close to the polymer, microorganisms in the plastisphere possess the advantage of degrading plastics. This study aims to investigate the bacterial community succession and obtain degrading bacteria in the plastisphere, as well as identify the most efficient degradation combination by co-culture of multiple strains. The findings demonstrate the alpha-diversity indices of the ...
DOI:
10.1016/j.jhazmat.2022.130045

4. Dopamine-induced abiotic stress tolerance in horticultural plants

Author:
Golam Jalal Ahammed; Xin Li
Source:
Scientia horticulturae 2023 v.307 pp. 111506
ISSN:
0304-4238
Subject:
xenobiotics,   etc   ; antioxidant activity; biomass production; biosynthesis; carbon dioxide; climate change; dopamine; drought; ethylene; horticulture; nitrates; nitrogen; nutrient deficiencies; oxidative stress; photochemistry; photosynthesis; pollutants; reactive oxygen species; salinity; salt stress; stomatal conductance; stress tolerance;     Show all 22 Subjects
Abstract:
... Dopamine is a naturally occurring amine in plants and animals, having a strong antioxidative capacity. Different abiotic stressors, such as drought, salinity, and nutrient deficiency induce endogenous dopamine biosynthesis, while exogenous dopamine application confers tolerance to abiotic stress. Plants benefit from exogenous dopamine to promote photosynthetic pigment concentrations, stomatal cond ...
DOI:
10.1016/j.scienta.2022.111506

5. Selective detection of carboxylesterase 2 activity in cancer cells using an activity-based chemiluminescent probe

Author:
Cagri Ozsan; Karishma Kailass; Elyse M. Digby; Toghrul Almammadov; Andrew A. Beharry; Safacan Kolemen
Source:
Chemical communications 2022 v.58 no.78 pp. 10929-10932
ISSN:
1364-548X
Subject:
xenobiotics,   etc   ; carboxylesterase; chemiluminescence; metabolism;     Show all 4 Subjects
Abstract:
... Carboxylesterase 2 (CES2) has crucial roles in both xenobiotic metabolism and formation of pathogenic states including cancer. Thus, it is highly critical to monitor intracellular CES2 activity in living cancer cells. Here, we report a CES2 activatable phenoxy 1,2-dioxetane based chemiluminescent agent (CL-CES2). The probe exhibited a selective turn-on response in the presence of CES2 enzyme and e ...
DOI:
10.1039/d2cc03309g

6. Biological machinery for polycyclic aromatic hydrocarbons degradation: A review

Author:
Arfin Imam; Sunil Kumar Suman; Pankaj K. Kanaujia; Anjan Ray
Source:
Bioresource technology 2022 v.343 pp. 126121
ISSN:
0960-8524
Subject:
xenobiotics,   etc   ; bioremediation; biosurfactants; genes; metabolomics; technology;     Show all 6 Subjects
Abstract:
... Polycyclic aromatic hydrocarbons (PAHs) are hazardous environmental pollutants with widespread and well-recognized health concerns. Amidst more than a hundred known PAHs, 16 are categorized as priority pollutants. Use of widely diverse biological machinery comprising bacteria, fungi, and algae harnessed from contaminated sites has emerged as an ecologically safe and sustainable approach for PAH de ...
DOI:
10.1016/j.biortech.2021.126121

7. Understanding the fundamentals of microbial remediation with emphasize on metabolomics

Author:
Vaishnavi Jeevanandam; Jabez Osborne
Source:
Preparative biochemistry & biotechnology 2022 v.52 no.3 pp. 351-363
ISSN:
1532-2297
Subject:
xenobiotics,   etc   ; biodegradation; bioremediation; biotechnology; genes; metabolites; metabolomics;     Show all 7 Subjects
Abstract:
... The post-genomic tool metabolomics is a great advancement in science and technology which acquires novel strategies and pathways to analyze various biological compounds. Metabolomics aids in retrieving the qualitative and quantitative data from the various biological system. The current review is focused on the application of metabolomics in bioremediation and helps to focus on the xenobiotic comp ...
DOI:
10.1080/10826068.2021.1946694

8. Pathologic, transcriptomic and microbiomic insight into the pathogenesis of intestinal parasitic tapeworm in cultured Chinese soft-shelled turtle (Pelodiscus sinensis)

Author:
Xianwen Zhou; Yu Tian; Li Liu; Lingrui Ge; Hui Zhang; Yixin Liang; Xiaoqing Wang; Yazhou Hu
Source:
Aquaculture 2023 v.562 pp. 738788
ISSN:
0044-8486
Subject:
xenobiotics,   etc   ; Citrobacter; Edwardsiella; Eucestoda; Pelodiscus sinensis; alanine transaminase; alkaline phosphatase; alpha-linolenic acid; aquaculture; arachidonic acid; aspartate transaminase; blood serum; creatinine; cytochrome P-450; epithelium; fish; gene expression regulation; glucose; histopathology; intestinal microorganisms; intestines; linoleic acid; lipid metabolism; liver; low density lipoprotein; mechanical damage; metabolic diseases; nutrition; pathogenesis; prediction; protein content; species identification; superoxide dismutase; tapeworms; transcriptomics; China;     Show all 36 Subjects
Abstract:
... Tapeworms are infamous and highly successful invasive parasites in aquatic animals, especially in fish. However, tapeworm-caused diseases in soft-shelled turtles are rarely discovered. In this study, a case of cultured Chinese soft-shelled turtle (Pelodiscus sinensis) infected with tapeworm in Changde city of China was reported, and the taxonomic identification of the tapeworm and the effects of t ...
DOI:
10.1016/j.aquaculture.2022.738788

9. Cellular Modifications of Rhodococci Exposed to Separate and Combined Effects of Pharmaceutical Pollutants

Author:
Irina Ivshina; Grigory Bazhutin; Semyon Tyan; Maxim Polygalov; Maria Subbotina; Elena Tyumina
Source:
Microorganisms 2022 v.10 no.6 pp. -
ISSN:
2076-2607
Subject:
xenobiotics,   etc   ; biotopes; catalase; early development; ibuprofen; meloxicam; toxicity;     Show all 7 Subjects
Abstract:
... Actinomycetes of the genus Rhodococcus (class Actinomycetia) are dominant dwellers of biotopes with anthropogenic load. They serve as a natural system of primary response to xenobiotics in open ecosystems, initiate defensive responses in the presence of pollutants, and are regarded as ideal agents capable of transforming and degrading pharmaceuticals. Here, the ability of selected Rhodococcus stra ...
DOI:
10.3390/microorganisms10061101

10. Old yellow enzyme of a novel fungi‐specific class

Author:
Kazuhiko Yamasaki
Source:
FEBS journal 2022 v.289 no.18 pp. 5527-5530
ISSN:
1742-464X
Subject:
xenobiotics,   etc   ; Ascochyta rabiei; NADPH dehydrogenase; flavoproteins; fungi; stereochemistry; stereoselectivity;     Show all 7 Subjects
Abstract:
... Old yellow enzymes (OYEs) are flavoproteins that catalyze stereoselective reduction of a wide variety of small molecules including xenobiotic toxins, and are considered as synthetic tools in industrial and pharmaceutical applications. Despite their broad specificity, differences in the enzyme structures influence the yield and stereochemistry of the products. Singh et al. present the three‐dimensi ...
DOI:
10.1111/febs.16526

11. Fe-based nanomaterial transformation to amorphous Fe: Enhanced alfalfa rhizoremediation of PCBs-contaminated soil

Author:
Ting Wu; Xinyi Liao; Yiting Zou; Yangzhi Liu; Kun Yang; Jason C. White; Daohui Lin
Source:
Journal of hazardous materials 2022 v.425 pp. 127973
ISSN:
0304-3894
Subject:
xenobiotics,   etc   ; Paraburkholderia; alfalfa; amino acids; carbohydrates; iron; nutrition; phytoremediation; rhizosphere;     Show all 9 Subjects
Abstract:
... Nano-enabled phytoremediation is an emerging remediation strategy for soils that are moderately contaminated with persistent organic contaminants, and there is a significant need for increased mechanistic understanding and for case studies. Herein, we evaluated the remediation of PCB28-contaminated soil using combined alfalfa and Fe-based materials, including zero-valent iron at 20 nm, 100 nm, and ...
DOI:
10.1016/j.jhazmat.2021.127973

12. New Aspects of the Antioxidant Activity of Glycyrrhizin Revealed by the CIDNP Technique

Author:
Aleksandra A. Ageeva; Alexander I. Kruppa; Ilya M. Magin; Simon V. Babenko; Tatyana V. Leshina; Nikolay E. Polyakov
Source:
Antioxidants 2022 v.11 no.8 pp. -
ISSN:
2076-3921
Subject:
xenobiotics,   etc   ; antioxidant activity; electron transfer; glycyrrhizin; licorice; oxygen; ultraviolet radiation;     Show all 7 Subjects
Abstract:
... Electron transfer plays a crucial role in ROS generation in living systems. Molecular oxygen acts as the terminal electron acceptor in the respiratory chains of aerobic organisms. Two main mechanisms of antioxidant defense by exogenous antioxidants are usually considered. The first is the inhibition of ROS generation, and the second is the trapping of free radicals. In the present study, we have e ...
DOI:
10.3390/antiox11081591

13. Use of Biostimulants as a New Approach for the Improvement of Phytoremediation Performance—A Review

Author:
Maria Luce Bartucca; Martina Cerri; Daniele Del Buono; Cinzia Forni
Source:
Plants 2022 v.11 no.15 pp. -
ISSN:
2223-7747
Subject:
xenobiotics,   etc   ; amino acids; crop production; energy; hydrolysates; macroalgae; phytoremediation; pollution;     Show all 8 Subjects
Abstract:
... Environmental pollution is one of the most pressing global issues, and it requires priority attention. Environmental remediation techniques have been developed over the years and can be applied to polluted sites, but they can have limited effectiveness and high energy consumption and costs. Bioremediation techniques, on the other hand, represent a promising alternative. Among them, phytoremediatio ...
DOI:
10.3390/plants11151946

14. Reaction-based fluorescent and chemiluminescent probes for formaldehyde detection and imaging

Author:
Shumei Huang; Zejun Li; Minghui Liu; Mengjiao Zhou; Jintao Weng; Yong He; Yin Jiang; Huatang Zhang; Hongyan Sun
Source:
Chemical communications 2022 v.58 no.10 pp. 1442-1453
ISSN:
1364-548X
Subject:
xenobiotics,   etc   ; breathing; carcinogens; chemiluminescence; diabetes; fluorescence; formaldehyde; heart; liver; metabolism; oxidoreductases;     Show all 11 Subjects
Abstract:
... Formaldehyde (FA), a reactive carbonyl species, is classified as Group 1 carcinogen by International Agency for Research on Cancer (IARC) in 2004. In addition, clinical studies have implicated that elevated levels of FA have been associated with different kinds of diseases, such as neurodegenerative diseases, diabetes, and chronic liver and heart disorders. However, in addition to the direct inhal ...
DOI:
10.1039/d1cc05644a

15. Local adaptation and spatiotemporal patterns of genetic diversity revealed by repeated sampling of Caenorhabditis elegans across the Hawaiian Islands

Author:
Timothy A. Crombie; Paul Battlay; Robyn E. Tanny; Kathryn S. Evans; Claire M. Buchanan; Daniel E. Cook; Clayton M. Dilks; Loraina A. Stinson; Stefan Zdraljevic; Gaotian Zhang; Nicole M. Roberto; Daehan Lee; Michael Ailion; Kathryn A. Hodgins; Erik C. Andersen
Source:
Molecular ecology 2022 v.31 no.8 pp. 2327-2347
ISSN:
0962-1083
Subject:
xenobiotics,   etc   ; Caenorhabditis briggsae; Caenorhabditis elegans; air; genetic variation; pathogens; Pacific Rim;     Show all 7 Subjects
Abstract:
... The nematode Caenorhabditis elegans is among the most widely studied organisms, but relatively little is known about its natural ecology. Genetic diversity is low across much of the globe but high in the Hawaiian Islands and across the Pacific Rim. To characterize the niche and genetic diversity of C. elegans on the Hawaiian Islands and to explore how genetic diversity might be influenced by local ...
DOI:
10.1111/mec.16400

16. Megalin, a multi-ligand endocytic receptor, and its participation in renal function and diseases: A review

Author:
Elsayed G.E. Elsakka; Mahmoud Mohamed Mokhtar; Maghawry Hegazy; Ahmed Ismail; Ahmed S. Doghish
Source:
Life sciences 2022 v.308 pp. 120923
ISSN:
0024-3205
Subject:
xenobiotics,   etc   ; diabetic nephropathy; endocytosis; half life; kidneys; renal function; toxicity; urine;     Show all 8 Subjects
Abstract:
... The endocytosis mechanism is a complicated system that is essential for cell signaling and survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such as cubilin, the neonatal Fc receptor for IgG, and NaPi-IIa are important in receptors-mediated endocytosis. Physiologically, megalin uptakes plasma vitamins and proteins from primary urine, preventing their loss. It al ...
DOI:
10.1016/j.lfs.2022.120923

17. Dietary Inhibitors of CYP3A4 Are Revealed Using Virtual Screening by Using a New Deep-Learning Classifier

Author:
Yelena Guttman; Zohar Kerem
Source:
Journal of agricultural and food chemistry 2022 v.70 no.8 pp. 2752-2761
ISSN:
1520-5118
Subject:
xenobiotics,   etc   ; bile; endocrine system; enzymes; food chemistry; humans; intestines; metabolism; models;     Show all 9 Subjects
Abstract:
... CYP3A4 is the main human enzyme responsible for phase I metabolism of dietary compounds, prescribed drugs and xenobiotics, steroid hormones, and bile acids. The inhibition of CYP3A4 activity might impair physiological mechanisms, including the endocrine system and response to drug admission. Here, we aimed to discover new CYP3A4 inhibitors from food and dietary supplements. A deep-learning model w ...
DOI:
10.1021/acs.jafc.2c00237

18. ABCG2/BCRP transport mechanism revealed through kinetically excited targeted molecular dynamics simulations

Author:
B. Dudas; X. Decleves; S. Cisternino; D. Perahia; M.A. Miteva
Source:
Computational and Structural Biotechnology Journal 2022 v.20 pp. 4195-4205
ISSN:
2001-0370
Subject:
xenobiotics,   etc   ; ABC transporters; biotechnology; drugs; estrone; exports; molecular dynamics; multiple drug resistance;     Show all 8 Subjects
Abstract:
... ABCG2/BCRP is an ABC transporter that plays an important role in tissue protection by exporting endogenous substrates and xenobiotics. ABCG2 is of major interest due to its involvement in multidrug resistance (MDR), and understanding its complex efflux mechanism is essential to preventing MDR and drug-drug interactions (DDI). ABCG2 export is characterized by two major conformational transitions be ...
DOI:
10.1016/j.csbj.2022.07.035

19. Behavioral Response in Toxicity Assessment of the Insecticide Decis® 2.5 EC toward Freshwater Zooplankton

Author:
Łukasz Sikorski; Agnieszka Bęś
Source:
Water 2022 v.14 no.13 pp. -
ISSN:
2073-4441
Subject:
xenobiotics,   etc   ; Daphnia magna; Ostracoda; agitation; deltamethrin; freshwater; liquids; plant protection; runoff; zooplankton;     Show all 10 Subjects
Abstract:
... Chemical crop protection agents are widely applied in modern agricultural practice. As a result of surface runoff, these insecticides penetrate into rivers, ponds, and lakes, where they become a serious threat to aquatic organisms. The aim of the study was to determine the toxicity of increasing concentrations of the insecticide Decis® 2.5 EC to Daphnia magna and Heterocypris incongruens, which ar ...
DOI:
10.3390/w14132059

20. Oxidative dehalogenation and mineralization of polychlorinated biphenyls by a resuscitated strain Streptococcus sp. SPC0

Author:
Qihua Lin; Xinru Zhou; Shusheng Zhang; Junliang Gao; Mengqi Xie; Linqin Tao; Faqian Sun; Chaofeng Shen; Muhammad Zaffar Hashmi; Xiaomei Su
Source:
Environmental research 2022 v.207 pp. 112648
ISSN:
0013-9351
Subject:
xenobiotics,   etc   ; Streptococcus; bioremediation; biphenyl; chlorides; dehalogenation; metabolites; mineralization; models; polychlorinated biphenyls; research;     Show all 11 Subjects
Abstract:
... Most functional microorganisms cannot be cultivated due to entering a viable but non-culturable (VBNC) state, which limits the characterization and application of polychlorinated biphenyl (PCB)-degrading strains. Resuscitating VBNC bacteria could provide huge candidates for obtaining high-efficient PCB degraders. However, limited studies have focused on the ability of resuscitated strains for PCBs ...
DOI:
10.1016/j.envres.2021.112648