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1. Visible light induced redox neutral fragmentation of 1,2-diol derivatives

Author:
Chatterjee, Anamitra,   et al.   ; Chen, Kang; Schwarz, Johanna; Karl, Tobias A.; König, Burkhard;     Show all 5 Authors
Source:
Chemical communications 2019 v.55 no.87 pp. 13144-13147
ISSN:
1364-548X
Subject:
acids; catalytic activity; chemical reactions; cleavage (chemistry); esters; hydrogen; ketones; light; lignin; models; phenols; reaction mechanisms
Abstract:
... A homogeneous, redox-neutral photo fragmentation of diol derivatives was developed. Under photo/hydrogen atom transfer (HAT) dual catalysis, diol derivatives such as lignin model compounds and diol monoesters undergo selective β C(sp³)–O bond cleavage to afford ketones, phenols and acids effectively. ...
DOI:
10.1039/c9cc06904f

2. Green Solvent for the Synthesis of Linear α-Olefins from Fatty Acids

Author:
Chatterjee, Anamitra,   et al.   ; Hopen Eliasson, Sondre H.; Occhipinti, Giovanni; Jensen, Vidar R.;     Show all 4 Authors
Source:
ACS sustainable chemistry & engineering 2019 v.7 no.5 pp. 4903-4911
ISSN:
2168-0485
Subject:
biomass; boiling point; catalysts; density functional theory; fatty acids; hydrogen; ligands; phosphine; solvents; temperature; toxic substances; toxicity
Abstract:
... Whereas transition-metal-catalyzed decarbonylative dehydration of fatty acids shows promise as a more sustainable route to α-olefins, the solvents used for this process have so far been toxic compounds such as N-methyl-2-pyrrolidone and 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone. Here, potential greener solvents are surveyed, using the well-defined precatalyst Pd(cinnamyl)Cl(DPEPhos) (1). ...
DOI:
10.1021/acssuschemeng.8b05523

3. Munc13 Is a Molecular Target of Bryostatin 1

Author:
Ghosh, Anamitra,   et al.   ; Blanco, Francisco A.; Czikora, Agnes; Kedei, Noemi; You, Youngki; Mitchell, Gary A.; Pany, Satyabrata; Blumberg, Peter M.; Das, Joydip;     Show all 9 Authors
Source:
Biochemistry 2019 v.58 no.27 pp. 3016-3030
ISSN:
1520-4995
Subject:
mechanism of action; memory; confocal microscopy; neurons; mice; protein kinase C; synaptic vesicles; macrolides; plasma membrane
Abstract:
... Bryostatin 1 is a natural macrolide shown to improve neuronal connections and enhance memory in mice. Its mechanism of action is largely attributed to the modulation of novel and conventional protein kinase Cs (PKCs) by binding to their regulatory C1 domains. Munc13-1 is a C1 domain-containing protein that shares common endogenous and exogenous activators with novel and conventional PKC subtypes. ...
DOI:
10.1021/acs.biochem.9b00427
PubMed:
31243993
PubMed Central:
PMC6620733

4. A minimalistic seasonal prediction model for Indian monsoon based on spatial patterns of rainfall anomalies

Author:
Saha, Anamitra,   et al.   ; Sahastrabuddhe, Rishi; Ghosh, Subimal; Murtugudde, Raghu;     Show all 4 Authors
Source:
Climate dynamics 2019 v.52 no.5-6 pp. 3661-3681
ISSN:
0930-7575
Subject:
El Nino; climate; models; monsoon season; prediction; rain; regression analysis; socioeconomic factors; spatial variation; surface water temperature; wind; India; Indian Ocean
Abstract:
... Seasonal prediction of Indian Summer Monsoon Rainfall (ISMR, rainfall during June to September over India) has remained an important scientific challenge for decades, due to its complex multi-scale nature. Statistical and dynamical seasonal ISMR predictions have traditionally relied on the relatively small variability of the spatially averaged monsoon rainfall over India, known as All India Monsoo ...
DOI:
10.1007/s00382-018-4349-2

5. Metabolic syndrome among rural Indian adults

Author:
Barik, Anamitra,   et al.   ; Das, Kausik; Chowdhury, Abhijit; Rai, Rajesh Kumar;     Show all 4 Authors
Source:
Clinical nutrition ESPEN 2018 v.23 pp. 129-135
ISSN:
2405-4577
Subject:
National Cholesterol Education Program; adults; body mass index; cardiovascular diseases; females; males; metabolic syndrome; mortality; noninsulin-dependent diabetes mellitus; overweight; physical activity; regression analysis; risk factors; underweight; weight loss; women; India
Abstract:
... To prevent an increasing level of mortality due to type 2 diabetes mellitus and cardiovascular disease among the rural Indian population, a management strategy of the metabolic syndrome (MetS) should be devised. This study aims to estimate the burden of MetS and its associated risk factors.Data from the Birbhum Population Project covering 9886 individuals (4810 male and 5076 female population) age ...
DOI:
10.1016/j.clnesp.2017.11.002

6. Underweight among rural Indian adults: burden, and predictors of incidence and recovery

Author:
Barik, Anamitra,   et al.   ; Rai, Rajesh Kumar; Fawzi, Wafaie Wahib; Bromage, Sabri; Chowdhury, Abhijit;     Show all 5 Authors
Source:
Public health nutrition 2018 v.21 no.4 pp. 669-678
ISSN:
1475-2727
Subject:
body mass index; cohort studies; educational status; monitoring; nutritional intervention; overweight; regression analysis; risk factors; underweight; young adults; India
Abstract:
... To study the magnitude and predictors of underweight, incident underweight and recovery from underweight among rural Indian adults. Prospective cohort study. Each participant’s BMI was measured in 2008 and 2012 and categorized as underweight (BMI<18·5 kg/m²), normal (BMI=18·5–22·9 kg/m²) or overweight/obese (BMI ≥23·0 kg/m²). Incident underweight was defined as a transition from normal weight or o ...
DOI:
10.1017/S1368980017003081
PubMed:
29122038

7. B-(3,3-Difluoroallyl)diisopinocampheylborane for the Enantioselective Fluoroallylboration of Aldehydes

Author:
Chatterjee, Anamitra,   et al.   ; Ramachandran, P. Veeraraghavan; Tafelska-Kaczmarek, Agnieszka;     Show all 3 Authors
Source:
Journal of organic chemistry 2012 v.77 no.20 pp. 9329-9333
ISSN:
1520-6904
Subject:
alcohols; aldehydes; chemical reactions; chemical structure; enantioselectivity; organic chemistry
Abstract:
... The fluoroallylboration of aldehydes with B-(3,3-difluoroallyl)diisopinocampheylborane, which was prepared via the hydroboration of 1,1-difluoroallene, provides chiral 2,2-gem-difluorinated homoallylic alcohols in good yields and 91–97% ee. ...
DOI:
10.1021/jo300970z

8. Resveratrol inhibits phorbol ester-induced membrane translocation of presynaptic Munc13-1

Author:
Ghosh, Anamitra,   et al.   ; Pany, Satyabrata; You, Youngki; Nguyen, Nga; Das, Joydip;     Show all 5 Authors
Source:
Biochimica et biophysica acta 2017 v.1861 no.11 pp. 2640-2651
ISSN:
0304-4165
Subject:
binding sites; confocal microscopy; cytosol; molecular models; mutants; neurodegenerative diseases; neurons; neuroprotective effect; neurotransmitters; plasma membrane; polyphenols; protein kinase C; resveratrol
Abstract:
... Resveratrol (1) is a naturally occurring polyphenol that has been implicated in neuroprotection. One of resveratrol's several biological targets is Ca²⁺-sensitive protein kinase C alpha (PKCα). Resveratrol inhibits PKCα by binding to its activator-binding C1 domain. Munc13-1 is a C1 domain-containing Ca²⁺-sensitive SNARE complex protein essential for vesicle priming and neurotransmitter release.To ...
DOI:
10.1016/j.bbagen.2017.07.006
PubMed:
28713022
PubMed Central:
PMC5623624

9. Generation and Trapping of a Cage Annulated Vinylidenecarbene and Approaches to Its Cycloalkyne Isomer

Author:
Chatterjee, Anamitra,   et al.   ; Sahu, Bichismitha; Gururaja, Guddeangadi N.; Kumar, Tarun; Ganguly, Bishwajit; Mobin, Shaikh M.; Namboothiri, Irishi N. N.;     Show all 7 Authors
Source:
Journal of organic chemistry 2012 v.77 no.16 pp. 6998-7004
ISSN:
1520-6904
Subject:
energy; isomers; organic chemistry; thermodynamics
Abstract:
... A novel cage-annulated (bis-homocubyl) vinylidenecarbene has been generated and successfully trapped without any intermediacy of its cycloalkyne isomer. The greater kinetic and thermodynamic stability of the vinylidenecarbene vis-à-vis its cycloalkyne isomer has been predicted by DFT B3LYP/6-31G* calculations. The calculated results suggest the prospects of the cycloalkyne becoming amenable for t ...
DOI:
10.1021/jo301215d

10. Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts

Author:
Chatterjee, Anamitra,   et al.   ; Pipalia, Nina H.; Cosner, Casey C.; Huang, Amy; Bourbon, Pauline; Farley, Nathan; Helquist, Paul; Wiest, Olaf; Maxfield, Frederick R.;     Show all 9 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.14 pp. 5620-5625
ISSN:
0027-8424
Subject:
blood-brain barrier; cholesterol; clinical trials; endosomes; fibroblasts; histone deacetylase; homeostasis; humans; lysosomes; models; mutants; mutation; neoplasms; phenotype; tissue culture
Abstract:
... Niemann-Pick type C (NPC) disease is predominantly caused by mutations in the NPC1 protein that affect intracellular cholesterol trafficking and cause accumulation of unesterified cholesterol and other lipids in lysosomal storage organelles. We report the use of a series of small molecule histone deacetylase (HDAC) inhibitors in tissue culture models of NPC human fibroblasts. Some HDAC inhibitors ...
DOI:
10.1073/pnas.1014890108
PubMed:
21436030
PubMed Central:
PMC3078401

11. Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease

Author:
Ghosh, Anamitra,   et al.   ; Roy, Avik; Liu, Xiaojuan; Kordower, Jeffrey H.; Mufson, Elliott J.; Hartley, Dean M.; Ghosh, Sankar; Mosley, R. Lee; Gendelman, Howard E.; Pahan, Kalipada;     Show all 10 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.47 pp. 18754-18759
ISSN:
0027-8424
Subject:
Parkinson disease; animal models; humans; mice; neurotransmitters; patients; therapeutics; transcription factor NF-kappa B
Abstract:
... Parkinson's disease (PD) is the second most common neurodegenerative disorder. Despite intense investigations, no effective therapy is available to stop its onset or halt its progression. The present study evaluates the ability of peptide corresponding to the NF-κB essential modifier-binding domain (NBD) of IκB kinase α (IKKα) or IKKβ to prevent nigrostriatal degeneration in the 1-methyl-4-phenyl- ...
DOI:
10.1073/pnas.0704908104
PubMed:
18000063
PubMed Central:
PMC2141849

12. The genome of Syntrophus aciditrophicus: Life at the thermodynamic limit of microbial growth

Author:
Bhattacharyya, Anamitra,   et al.   ; McInerney, Michael J.; Rohlin, Lars; Mouttaki, Housna; Kim, UnMi; Krupp, Rebecca S.; Rios-Hernandez, Luis; Sieber, Jessica; Struchtemeyer, Christopher G.; Campbell, John W.; Gunsalus, Robert P.;     Show all 11 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.18 pp. 7600-7605
ISSN:
0027-8424
Subject:
Syntrophus; acyl coenzyme A; aromatic acids; bacteria; biochemical pathways; biosphere; carbon; electron transfer; energy; genes; genomics; inventories; lifestyle; ligases; menaquinones; metabolism; microbial growth; nucleotide sequences; proteins; thermodynamics
Abstract:
... Biochemically, the syntrophic bacteria constitute the missing link in our understanding of anaerobic flow of carbon in the biosphere. The completed genome sequence of Syntrophus aciditrophicus SB, a model fatty acid- and aromatic acid-degrading syntrophic bacterium, provides a glimpse of the composition and architecture of the electron transfer and energy-transducing systems needed to exist on mar ...
DOI:
10.1073/pnas.0610456104
PubMed:
17442750
PubMed Central:
PMC1863511

13. Genome Sequence of the Fish Pathogen Renibacterium salmoninarum Suggests Reductive Evolution away from an Environmental Arthrobacter Ancestor

Author:
Bhattacharyya, Anamitra,   et al.   ; Wiens, Gregory D.; Rockey, Daniel D.; Wu, Zaining; Chang, Jean; Levy, Ruth; Crane, Samuel; Chen, Donald S.; Capri, Gina R.; Burnett, Jeffrey R.; Sudheesh, Ponnerassery S.; Schipma, Matthew J.; Burd, Henry; Rhodes, Linda D.; Kaul, Rajinder; Strom, Mark S.;     Show all 16 Authors
Source:
Journal of bacteriology 2008 v.190 no.21 pp. 6970
ISSN:
1098-5530
Subject:
Renibacterium salmoninarum; animal pathogenic bacteria; genomics; bacterial infections; fish diseases; Arthrobacter; molecular systematics; phylogeny; fish culture; microbial physiology; amino acid metabolism; lipid metabolism
Abstract:
... Renibacterium salmoninarum is the causative agent of bacterial kidney disease and a significant threat to healthy and sustainable production of salmonid fish worldwide. This pathogen is difficult to culture in vitro, genetic manipulation is challenging, and current therapies and preventative strategies are only marginally effective in preventing disease. The complete genome of R. salmoninarum ATCC ...
Handle:
10113/40699
DOI:
10.1128/JB.00721-08
PubMed:
18723615
PubMed Central:
PMC2580684