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1. Ability of near-infrared spectroscopy and chemometrics to predict the age of mosquitoes reared under different conditions

Author:
Ong, Oselyne T. W.; Kho, Elise A.; Esperança, Pedro M.; Freebairn, Chris; Dowell, Floyd E.; Devine, Gregor J.; Churcher, Thomas S.
Source:
Parasites & vectors 2020 v.13 no.1 pp. 160
ISSN:
1756-3305
Subject:
Aedes albopictus; absorbance; adults; age structure; artificial intelligence; chemometrics; environmental factors; females; insect vectors; laboratory rearing; least squares; models; near-infrared spectroscopy; prediction; principal component analysis; pupae; spectral analysis; vectorial capacity
Abstract:
... BACKGROUND: Practical, field-ready age-grading tools for mosquito vectors of disease are urgently needed because of the impact that daily survival has on vectorial capacity. Previous studies have shown that near-infrared spectroscopy (NIRS), in combination with chemometrics and predictive modeling, can forecast the age of laboratory-reared mosquitoes with moderate to high accuracy. It remains uncl ...
DOI:
10.1186/s13071-020-04031-3
PubMed:
32228670
PubMed Central:
PMC7106667

2. A bioinformatics investigation into the pharmacological mechanisms of the effect of the Yinchenhao decoction on hepatitis C based on network pharmacology

Author:
Zhang, Jingyuan; Liu, Xinkui; Wu, Jiarui; Zhou, Wei; Tian, Jinhui; Guo, Siyu; Jia, Shan Shan; Meng, Ziqi; Ni, Mengwei
Source:
BMC complementary medicine and therapies 2020 v.20 no.1 pp. 50
ISSN:
2662-7671
Subject:
Hepatitis C virus; active ingredients; bioinformatics; computer simulation; gall bladder; gene ontology; genes; hepatitis A; hepatitis C; hepatoma; herbal medicines; liver; mechanism of action; pathogenesis; pharmacology; prediction; protein-protein interactions; proteins; signal transduction; tumor necrosis factors; China
Abstract:
... BACKGROUND: Globally, more than 170 million people are infected with hepatitis C virus, a major cause of cirrhosis and hepatocellular carcinoma. The Yinchenhao Decoction (YCHD) is a classic formula comprising three herbal medicines. This decoction have long been used in China for clinically treating acute and chronic infectious hepatitis and other liver and gallbladder damp heat-accumulation disor ...
DOI:
10.1186/s12906-020-2823-y
PubMed:
32050950
PubMed Central:
PMC7076901

3. Acetylation at K108 of the NS1 protein is important for the replication and virulence of influenza virus

Author:
Ma, Jingjiao; Wu, Rujuan; Xu, Guanlong; Cheng, Yuqiang; Wang, Zhaofei; Wang, Heng’an; Yan, Yaxian; Li, Jinxiang; Sun, Jianhe
Source:
Veterinary research 2020 v.51 no.1 pp. 20
ISSN:
1297-9716
Subject:
Orthomyxoviridae; acetylation; interferon-beta; mutants; mutation; viral nonstructural proteins; virulence; virus replication; viruses
Abstract:
... Non-structural protein 1 (NS1) of influenza virus is a multifunctional protein that plays an important role in virus replication and virulence. In this study, an acetylation modification was identified at the K108 residue of the NS1 protein of H1N1 influenza virus. To further explore the function of the K108 acetylation modification of the NS1 protein, a deacetylation-mimic mutation (K108R) and a ...
DOI:
10.1186/s13567-020-00747-3
PubMed:
32093780
PubMed Central:
PMC7038556

4. A comparison of respiratory function in pigs anaesthetised by propofol or alfaxalone in combination with dexmedetomidine and ketamine

Author:
Lervik, Andreas; Toverud, Simen Forr; Krontveit, Randi; Haga, Henning Andreas
Source:
Acta veterinaria scandinavica 2020 v.62 no.1 pp. 14
ISSN:
1751-0147
Subject:
alfaxalone; anesthesia; body weight; carbon dioxide; dexmedetomidine; intravenous injection; ketamine; lung function; oxygen; respiratory rate; swine; tidal volume
Abstract:
... BACKGROUND: General anaesthesia in pigs maintained with intravenous drugs such as propofol may cause respiratory depression. Alfaxalone gives less respiratory depression than propofol in some species. The aim of the investigation was to compare respiratory effects of propofol–ketamine–dexmedetomidine and alfaxalone–ketamine–dexmedetomidine in pigs. Sixteen pigs premedicated with ketamine 15 mg/kg ...
DOI:
10.1186/s13028-020-0512-y
PubMed:
32164761
PubMed Central:
PMC7066810

5. A comparison of self-reported and device measured sedentary behaviour in adults: a systematic review and meta-analysis

Author:
Prince, Stephanie A.; Cardilli, Luca; Reed, Jennifer L.; Saunders, Travis J.; Kite, Chris; Douillette, Kevin; Fournier, Karine; Buckley, John P.
Source:
The international journal of behavioral nutrition and physical activity 2020 v.17 no.1 pp. 31
ISSN:
1479-5868
Subject:
accelerometers; adults; chronic diseases; databases; meta-analysis; mortality; questionnaires; risk factors; sedentary lifestyle; systematic review
Abstract:
... BACKGROUND: Sedentary behaviour (SB) is a risk factor for chronic disease and premature mortality. While many individual studies have examined the reliability and validity of various self-report measures for assessing SB, it is not clear, in general, how self-reported SB (e.g., questionnaires, logs, ecological momentary assessments (EMAs)) compares to device measures (e.g., accelerometers, inclino ...
DOI:
10.1186/s12966-020-00938-3
PubMed:
32131845
PubMed Central:
PMC7055033

6. A convenient, rapid and efficient method for establishing transgenic lines of Brassica napus

Author:
Zhang, Kai; He, Jianjie; Liu, Lu; Xie, Runda; Qiu, Lu; Li, Xicheng; Yuan, Wenjue; Chen, Kang; Yin, Yongtai; Kyaw, May Me Me; San, Aye Aye; Li, Shisheng; Tang, Xianying; Fu, Chunhua; Li, Maoteng
Source:
Plant methods 2020 v.16 no.1 pp. 43
ISSN:
1746-4811
Subject:
Brassica napus; biomass; breeding; cotyledons; culture media; fluorescence; genes; genetic transformation; hypocotyls; oilseed crops; plantlets; rapeseed; roots; screening; seed coat; seed germination; seedlings; tissue culture; tissues; transgenic plants; vegetable oil
Abstract:
... BACKGROUND: Brassica napus is an important oilseed crop that offers a considerable amount of biomass for global vegetable oil production. The establishment of an efficient genetic transformation system with a convenient transgenic-positive screening method is of great importance for gene functional analysis and molecular breeding. However, to our knowledge, there are few of the aforementioned syst ...
DOI:
10.1186/s13007-020-00585-6
PubMed:
32256679
PubMed Central:
PMC7106750

7. A cross-sectional study of obesogenic behaviours and family rules according to family structure in European children

Author:
Stahlmann, Katharina; Hebestreit, Antje; DeHenauw, Stefaan; Hunsberger, Monica; Kaprio, Jaakko; Lissner, Lauren; Molnár, Dénes; Ayala-Marín, Alelí M.; Reisch, Lucia A.; Russo, Paola; Tornaritis, Michael; Veidebaum, Toomas; Pohlabeln, Hermann; Bogl, Leonie H.
Source:
The international journal of behavioral nutrition and physical activity 2020 v.17 no.1 pp. 32
ISSN:
1479-5868
Subject:
adolescents; adults; body mass index; boys; children; computers; cross-sectional studies; educational status; family structure; girls; kinship; obesity; parents; questionnaires; regression analysis; sleep; sugar sweetened beverages; television; Europe
Abstract:
... BACKGROUND: There has been an increase in children growing up in non-traditional families, such as single-parent and blended families. Children from such families have a higher prevalence of obesity and poorer health outcomes, but research on the relationship with obesogenic behaviours is limited. OBJECTIVES: Therefore, the aim of this study was to investigate whether there are associations betwee ...
DOI:
10.1186/s12966-020-00939-2
PubMed:
32138743
PubMed Central:
PMC7059256

8. Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter

Author:
Kim, Ji-Sun; Oh, Jeong-Min; Choi, Hyunsu; Kim, Sung Won; Kim, Soo Whan; Kim, Byung Guk; Cho, Jin Hee; Lee, Joohyung; Lee, Dong Chang
Source:
BMC complementary medicine and therapies 2020 v.20 no.1 pp. 101
ISSN:
2662-7671
Subject:
Western blotting; antioxidant activity; chronic diseases; curcumin; dose response; fibroblasts; flow cytometry; humans; mitogen-activated protein kinase; nose; oxidative stress; particulates; patients; reactive oxygen species; rhinitis
Abstract:
... BACKGROUND: Particulate matter (PM) can cause various negative acute and chronic diseases of the respiratory system, including the upper airways. Curcumin has been reported to have anti-inflammatory and anti-oxidative effects; therefore, we investigated the effects of curcumin on nasal fibroblasts exposed to urban PM (UPM). METHODS: Samples of inferior turbinate tissue were obtained from six patie ...
DOI:
10.1186/s12906-020-02886-8
PubMed:
32228565
PubMed Central:
PMC7106591

9. Active learning with point supervision for cost-effective panicle detection in cereal crops

Author:
Chandra, Akshay L.; Desai, Sai Vikas; Balasubramanian, Vineeth N.; Ninomiya, Seishi; Guo, Wei
Source:
Plant methods 2020 v.16 no.1 pp. 34
ISSN:
1746-4811
Subject:
Sorghum (Poaceae); Triticum aestivum; agronomists; automation; computer vision; cost effectiveness; crop management; crop yield; data collection; detectors; grain crops; grain sorghum; learning; models; panicles; phenotype; plant breeders; variance; wheat
Abstract:
... BACKGROUND: Panicle density of cereal crops such as wheat and sorghum is one of the main components for plant breeders and agronomists in understanding the yield of their crops. To phenotype the panicle density effectively, researchers agree there is a significant need for computer vision-based object detection techniques. Especially in recent times, research in deep learning-based object detectio ...
DOI:
10.1186/s13007-020-00575-8
PubMed:
32161624
PubMed Central:
PMC7060654

10. A cucumber green mottle mosaic virus vector for virus-induced gene silencing in cucurbit plants

Author:
Liu, Mei; Liang, Zhiling; Aranda, Miguel A.; Hong, Ni; Liu, Liming; Kang, Baoshan; Gu, Qinsheng
Source:
Plant methods 2020 v.16 no.1 pp. 9
ISSN:
1746-4811
Subject:
Cucumber green mottle mosaic virus; Lagenaria siceraria; Nicotiana benthamiana; breeding; complementary DNA; cucumbers; enzymes; fruits; gene silencing; genes; genetic transformation; genome mining; models; pathogens; phenotype; photobleaching; viruses; watermelons
Abstract:
... BACKGROUND: Cucurbits produce fruits or vegetables that have great dietary importance and economic significance worldwide. The published genomes of at least 11 cucurbit species are boosting gene mining and novel breeding strategies, however genetic transformation in cucurbits is impractical as a tool for gene function validation due to low transformation efficiency. Virus-induced gene silencing (V ...
DOI:
10.1186/s13007-020-0560-3
PubMed:
32025236
PubMed Central:
PMC6996188

11. Acute and chronic effects of multivitamin/mineral supplementation on objective and subjective energy measures

Author:
Dodd, F. L.; Kennedy, D. O.; Stevenson, E. J.; Veasey, R. C.; Walker, K.; Reed, S.; Jackson, P. A.; Haskell-Ramsay, C. F.
Source:
Nutrition & metabolism 2020 v.17 no.1 pp. 16
ISSN:
1743-7075
Subject:
acute effects; carbohydrates; coenzyme Q10; cognition; dietary recommendations; energy expenditure; energy metabolism; exercise; females; ferritin; long term effects; males; men; minerals; oxidation; water-soluble vitamins; women
Abstract:
... BACKGROUND: Vitamins and minerals play an essential role within many cellular processes including energy production and metabolism. Previously, supplementation with a multivitamin/mineral (MVM) for ≥28 days resulted in improvements to cognition and subjective state. We have also demonstrated shifts in metabolism during cognitively demanding tasks following MVM in females, both acutely and followin ...
DOI:
10.1186/s12986-020-00435-1
PubMed:
32123534
PubMed Central:
PMC7038616

12. Acute and sub-acute toxicity of Echinops kebericho decoction in rats

Author:
Deyno, Serawit; Abebe, Abiy; Tola, Mesfin Asefa; Hymete, Ariya; Bazira, Joel; Makonnen, Eyasu; Alele, Paul E.
Source:
BMC complementary medicine and therapies 2020 v.20 no.1 pp. 2
ISSN:
2662-7671
Subject:
Echinops; acute toxicity; albino; analysis of variance; antimalarials; chemistry; childbirth; creatinine; fatty liver; females; food consumption; fumigation; guidelines; hematology; histopathology; insect repellents; laboratory animals; lethal dose 50; lungs; males; monocytes; mortality; oral administration; rats; standard deviation; tissue weight; toxicity testing; triacylglycerols
Abstract:
... BACKGROUND: Echinops kebericho is widely used for treatment of a variety of diseases including infectious, non-infectious disease and fumigation during child birth. Antibacterial, antimalarial, anti-leshimania, anti-diarrheal and insect repellent activities have been elucidated. Its toxicity profile is not yet investigated and thus this study was to investigate acute and sub-acute toxicity of E. k ...
DOI:
10.1186/s12906-019-2794-z
PubMed:
32020865
PubMed Central:
PMC7076833

13. Acute tea tree oil intoxication in a pet cockatiel (Nymphicus hollandicus): a case report

Author:
Vetere, Alessandro; Bertocchi, Mara; Pelizzone, Igor; Moggia, Emanuele; Travaglino, Chiara; Della Grotta, Mariangela; Casali, Silvia; Gerosa, Sebastiano; Strada, Laura; Filia, Katia; Casalini, Jacopo; Parmigiani, Enrico; Di Ianni, Francesco
Source:
BMC veterinary research 2020 v.16 no.1 pp. 29
ISSN:
1746-6148
Subject:
Melaleuca; birds; blood; case studies; clinical examination; essential oils; fluid therapy; heavy metals; hematologic tests; males; neutropenia; patients; pet care; pets; phytotherapy; poisoning; poisonous plants; tea tree oil; toxicity; veterinary clinics
Abstract:
... BACKGROUND: Phytotherapy is becoming a more and more common practice, not only for personal care but also for pet care. Nevertheless, we often have to deal with substances on which, in most cases, very little literature is available, even more so if the species of interest are the exotic ones. In particular, the essential oil from the Melaleuca leaves, because of its antinflammatory and antibacter ...
DOI:
10.1186/s12917-020-2255-4
PubMed:
32005244
PubMed Central:
PMC6995176

14. A de novo variant in OTX2 in a lamb with otocephaly

Author:
Paris, Julia Maria; Letko, Anna; Häfliger, Irene Monika; Švara, Tanja; Gombač, Mitja; Klinc, Primož; Škibin, Andrej; Pogorevc, Estera; Drögemüller, Cord
Source:
Acta veterinaria scandinavica 2020 v.62 no.1 pp. 5
ISSN:
1751-0147
Subject:
DNA; abnormal development; animal pathology; brain; cleft palate; esophagus; haploinsufficiency; head; heterozygosity; homeodomain proteins; loss-of-function mutation; males; mandible (bone); neck; parents; sequence analysis; sheep; sheep diseases; stop codon; transcription factors
Abstract:
... BACKGROUND: Otocephaly is a rare lethal malformation of the first branchial arch. While the knowledge on the causes of otocephaly in animals is limited, different syndromic forms in man are associated with variants of the PRRX1 and OTX2 genes. CASE PRESENTATION: A stillborn male lamb of the Istrian Pramenka sheep breed showed several congenital craniofacial anomalies including microstomia, agnathi ...
DOI:
10.1186/s13028-020-0503-z
PubMed:
31969185
PubMed Central:
PMC6977343

15. A DIVA vaccine strain lacking RpoS and the secondary messenger c-di-GMP for protection against salmonellosis in pigs

Author:
Gil, Carmen; Latasa, Cristina; García-Ona, Enrique; Lázaro, Isidro; Labairu, Javier; Echeverz, Maite; Burgui, Saioa; García, Begoña; Lasa, Iñigo; Solano, Cristina
Source:
Veterinary research 2020 v.51 no.1 pp. 3
ISSN:
1297-9716
Subject:
immunologic techniques; salmonellosis; second messengers; swine; vaccines
Abstract:
... Salmonellosis is the second most common food-borne zoonosis in the European Union, with pigs being a major reservoir of this pathogen. Salmonella control in pig production requires multiple measures amongst which vaccination may be used to reduce subclinical carriage and shedding of prevalent serovars, such as Salmonella enterica serovar Typhimurium. Live attenuated vaccine strains offer advantage ...
DOI:
10.1186/s13567-019-0730-3
PubMed:
31924274
PubMed Central:
PMC6954585

16. A European proposal for quality control and quality assurance of tandem mass spectral libraries

Author:
Oberacher, Herbert; Sasse, Michael; Antignac, Jean-Philippe; Guitton, Yann; Debrauwer, Laurent; Jamin, Emilien L.; Schulze, Tobias; Krauss, Martin; Covaci, Adrian; Caballero-Casero, Noelia; Rousseau, Kathleen; Damont, Annelaure; Fenaille, François; Lamoree, Marja; Schymanski, Emma L.
Source:
Environmental sciences Europe 2020 v.32 no.1 pp. 43
ISSN:
2190-4707
Subject:
data collection; databases; environmental monitoring; quality control; reference standards; screening; tandem mass spectrometry
Abstract:
... BACKGROUND: High resolution mass spectrometry (HRMS) is being used increasingly in the context of suspect and non-targeted screening for the identification of bioorganic molecules. There is correspondingly increasing awareness that higher confidence identification will require a systematic, group effort to increase the fraction of compounds with tandem mass spectra available in central, publicly a ...
DOI:
10.1186/s12302-020-00314-9

17. A field study in support of the monitoring of priority substances in German freshwater fish: derivation of fillet-to-whole fish conversion factors

Author:
Rüdel, Heinz; Radermacher, Georg; Fliedner, Annette; Lohmann, Nina; Duffek, Anja
Source:
Environmental sciences Europe 2020 v.32 no.1 pp. 13
ISSN:
2190-4707
Subject:
aquatic environment; biometry; compliance; dioxins; environmental quality; fillets; freshwater; freshwater fish; hexabromocyclododecane; hexachlorobenzene; human health; mercury; perfluorooctane sulfonic acid; poisoning; polybrominated diphenyl ethers; risk; risk assessment; rivers; sulfonic acids; surface water; wildlife; Germany
Abstract:
... BACKGROUND: Bioaccumulating contaminants in surface waters are preferably monitored in fish for assessing the related risks to and via the aquatic environment. Consequently, the European Water Framework Directive (WFD) requires a monitoring of certain priority substances such as mercury, polybrominated diphenyl ethers (PBDE), perfluorooctane sulfonic acid and its derivatives (PFOS), hexachlorobenz ...
DOI:
10.1186/s12302-020-0295-9

18. A high throughput method for quantifying number and size distribution of Arabidopsis seeds using large particle flow cytometry

Author:
Morales, Alejandro; Teapal, J.; Ammerlaan, J. M. H.; Yin, X.; Evers, J. B.; Anten, N. P. R.; Sasidharan, R.; van Zanten, M.
Source:
Plant methods 2020 v.16 no.1 pp. 27
ISSN:
1746-4811
Subject:
Arabidopsis thaliana; algorithms; chaff; computer software; dust; flow cytometry; phenotype; prediction; seed size; seeds
Abstract:
... BACKGROUND: Seed size and number are important plant traits from an ecological and horticultural/agronomic perspective. However, in small-seeded species such as Arabidopsis thaliana, research on seed size and number is limited by the absence of suitable high throughput phenotyping methods. RESULTS: We report on the development of a high throughput method for counting seeds and measuring individual ...
DOI:
10.1186/s13007-020-00572-x
PubMed:
32158493
PubMed Central:
PMC7053093

19. A high-throughput screening method to identify proteins involved in unfolded protein response of the endoplasmic reticulum in plants

Author:
Alcântara, André; Seitner, Denise; Navarrete, Fernando; Djamei, Armin
Source:
Plant methods 2020 v.16 no.1 pp. 4
ISSN:
1746-4811
Subject:
Nicotiana benthamiana; Ustilago zeae; biocenosis; corn; endoplasmic reticulum; fungal proteins; gene expression regulation; genes; high-throughput screening methods; leaves; plant pathogens; protein secretion; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; unfolded protein response; yellow fluorescent protein
Abstract:
... BACKGROUND: The unfolded protein response (UPR) is a highly conserved process in eukaryotic organisms that plays a crucial role in adaptation and development. While the most ubiquitous components of this pathway have been characterized, current efforts are focused on identifying and characterizing other UPR factors that play a role in specific conditions, such as developmental changes, abiotic cue ...
DOI:
10.1186/s13007-020-0552-3
PubMed:
31988651
PubMed Central:
PMC6971872

20. Akkermansia muciniphila protects intestinal mucosa from damage caused by S. pullorum by initiating proliferation of intestinal epithelium

Author:
Zhu, Linda; Lu, Xiaoxi; Liu, Li; Voglmeir, Josef; Zhong, Xiang; Yu, Qinghua
Source:
Veterinary research 2020 v.51 no.1 pp. 34
ISSN:
1297-9716
Subject:
bacteria; beta catenin; chickens; chicks; colon; enteropathogens; goblet cells; inflammation; intestinal mucosa; mucins; obesity; proliferating cell nuclear antigen; signal transduction
Abstract:
... Akkermansia muciniphila, a novel mucin-degrading bacterium, has been demonstrated to prevent the development of obesity and related complications. However, whether it can protect poultry from intestinal mucosal damage by enteropathogens has never been mentioned. In this study, we found that A. muciniphila colonized in the intestine and then relieved intestinal mucosal damage in chicks caused by S. ...
DOI:
10.1186/s13567-020-00755-3
PubMed:
32138776
PubMed Central:
PMC7057645