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Challenges and opportunities in the advancement of nanomedicines
- Wei, Alexander, Mehtala, Jonathan G., Patri, Anil K.
- Journal of controlled release 2012 v.164 no.2 pp. 236-246
- adsorption, bioaccumulation, bioavailability, cytotoxicity, engineering, excretion, nanocarriers, nanoparticles
- Nanomedicine-based approaches to cancer treatment face several challenges that differ from those encountered by conventional medicines during clinical development. A systematic exploration of these issues has led us to identify the following needs and opportunities for further development: (1) robust and general methods for the accurate characterization of nanoparticle size, shape, and composition; (2) scalable approaches for producing nanomedicines with optimized bioavailability and excretion profiles; (3) particle engineering for maintaining low levels of nonspecific cytotoxicity and sufficient stability during storage; (4) optimization of surface chemistries for maximum targeted delivery and minimum nonspecific adsorption; (5) practical methods for quantifying ligand density and distributions on multivalent nanocarriers; and (6) the design of multifunctional nanomedicines for novel combination therapies with supportable levels of bioaccumulation.