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IFITMs Restrict the Replication of Multiple Pathogenic Viruses
- Perreira, Jill M., Chin, Christopher R., Feeley, Eric M., Brass, Abraham L.
- Journal of Molecular Biology 2013 v.425 pp. 4937-4955
- Dengue virus, Ebolavirus, Hepatitis C virus, Orthomyxoviridae, pathogenesis, viruses
- The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and Ebola virus. This review covers recent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of action, and impact on pathogenesis.