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Mild and efficient barbier allylation reaction mediated by magnesium powder under solvent-free conditions

Author:
Li, Shunxi, Wang, Jin-Xian, Wen, Xiaoliu, Ma, Xiaofang
Source:
Tetrahedron 2011 v.67 no.5 pp. 849-855
ISSN:
0040-4020
Subject:
alcohols, aldehydes, carbonyl compounds, chemical reactions, chemical structure, ketones, magnesium, temperature
Abstract:
A novel and highly efficient synthesis of homoallylic alcohols is achieved by the allylation of carbonyl compounds using magnesium powder as mediator under solvent-free conditions. A series of aldehydes and ketones are converted to the corresponding homoallylic alcohols, the yields of the reaction is considerably high (85–98%). The procedure is environment benign, operationally simple and easy to scale up at room temperature.
Agid:
1093397