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Efficient copper-induced coupling between NH-fluoroalkylated sulfoximines and aryl iodides or bromides

Author:
Macé, Yohan, Pégot, Bruce, Guillot, Régis, Bournaud, Chloée, Toffano, Martial, Vo-Thanh, Giang, Magnier, Emmanuel
Source:
Tetrahedron 2011 v.67 no.39 pp. 7575-7580
ISSN:
0040-4020
Subject:
bromides, chemical reactions, chemical structure, copper, heterocyclic compounds, iodides
Abstract:
A high yielding, simple, and flexible copper-based system for N-arylation of fluorinated sulfoximines is reported. Best results were achieved using copper iodide in combination with DMEDA and Cs₂CO₃ to provide a wide range of N-arylated perfluoroalkylated sulfoximines. These conditions tolerate a great number of substituents on either aromatic cycle, including heteroaromatic rings, for the N-functionalization.
Agid:
1094161