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Synthesis of benzoindoloquinolizines via a Cu(I)-mediated C–N bond formation

Author:
Worayuthakarn, Rattana, Nealmongkol, Prattya, Ruchirawat, Somsak, Thasana, Nopporn
Source:
Tetrahedron 2012 v.68 no.13 pp. 2864-2875
ISSN:
0040-4020
Subject:
chemical structure, copper, deamination, isoquinolines
Abstract:
An effective synthesis of the multi ring-fused benzoindoloquinolizines has been accomplished by Cu(I)-mediated and MW-assisted C–Nₐₘᵢdₑ bond formation of benzo[a]quinolizin-4-ones. The deamination of tetrahydro-2H-pyrido[2,1-a]isoquinolines was also studied and was found to give benzoquinolizines. The benzo[a]quinolizin-4-ones were prepared based on the annulations of C-1 substituted 3,4-dihydroisoquinolines and azlactones.
Agid:
1094774