PubAg

Main content area

Iodo–sesquiterpene hydroquinone and brominated indole alkaloids from the Thai sponge Smenospongia sp.

Author:
Prawat, Hunsa, Mahidol, Chulabhorn, Kaweetripob, Wirongrong, Wittayalai, Sawangjitt, Ruchirawat, Somsak
Source:
Tetrahedron 2012 v.68 no.34 pp. 6881-6886
ISSN:
0040-4020
Subject:
chemical reactions, chemical structure, cytotoxicity, ergosterol, hydroquinone, indole alkaloids, metabolites, neoplasm cells, spectroscopy
Abstract:
6′-Iodoaureol, an iodo–sesquiterpene hydroquinone, 6′-aureoxyaureol, a bissesquiterpene hydroquinone, and four brominated indole alkaloids 3–6 were isolated from the Thai sponge Smenospongia sp. Additionally, four known sesquiterpene hydroquinones 12–15, ten known brominated indole alkaloids 7–11, 17–18, and 20–22, ergosterol, and furospinosulin-1 were also isolated. Compound 1 is the first reported iodo–sesquiterpene hydroquinone and compounds 7–11 were isolated for the first time from natural sources. The structures were characterized by spectroscopic analyses as well as comparison with literature data. Several of these metabolites were evaluated for cytotoxic activity against seven tumor cell lines.
Agid:
1095235