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Cu(I)-mediated lactone formation in subcritical water: a benign synthesis of benzopyranones and urolithins A–C

Author:
Nealmongkol, Prattya, Tangdenpaisal, Kassrin, Sitthimonchai, Somkid, Ruchirawat, Somsak, Thasana, Nopporn
Source:
Tetrahedron 2013 v.69 pp. 9277-9283
ISSN:
0040-4020
Subject:
antioxidant activity, chemical reactions, chemical structure, copper, metabolites, organic compounds
Abstract:
Benzopyranones were successfully synthesized using Cu(I)-mediated C–O bond formation in subcritical water. A number of benzopyranone derivatives including polymethoxy benzopyranones, benzopyranopyridones, chromenoindolones, and furochromenones were synthesized in satisfactory yield. This methodology was further applied to synthesize the intestinal microbial metabolites, urolithins A, B, and C, which were found to exhibit potent antioxidant activity.
Agid:
1096744