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A novel calixsalen macrocycle: metal sensing behavior for Zn²⁺ and intracellular imaging application
- Fu, Yong, Xing, Zhitao, Zhu, Chengcheng, Yang, Hongwei, He, Weijiang, Zhu, Chengjian, Cheng, Yixiang
- Tetrahedron letters 2012 v.53 no.7 pp. 804-807
- cations, chemical reactions, crystal structure, fluorescence, image analysis, organic compounds, stoichiometry, zinc
- The chiral [3+3] macrocycle 1 which displays a calixarene-like crystal structure has been synthesized. The UV/Vis and fluorescence spectral studies show that 1 and Zn²⁺ have a 1:3 complex stoichiometry. It exhibits high selectivity toward Zn²⁺, but no significant responses toward other competitive cations. The intracellular imaging ability has been tested in HeLa cells using a confocal microscope.