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Easily accessible chiral dicyclopentadiene ligands for rhodium-catalyzed enantioselective 1,4-addition reactions
- Shao, Cheng, Yu, Hong-Jie, Feng, Chen-Guo, Wang, Rui, Lin, Guo-Qiang
- Tetrahedron letters 2012 v.53 no.22 pp. 2733-2735
- carbonyl compounds, chemical reactions, enantiomers
- A variety of novel C₁-symmetric chiral diene ligands based on the dicyclopentadiene (DCP) skeleton were easily prepared from commercially available DCP. The application of these diene ligands in the rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to α,β-unsaturated carbonyl compounds has been examined and excellent enantioselectivities (up to 97% ee) as well as good yields were achieved under mild reaction conditions.