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Brönsted acid hydrotrope combined catalyst for environmentally benign synthesis of quinoxalines and pyrido[2,3-b]pyrazines in aqueous medium
- Kumbhar, Arjun, Kamble, Santosh, Barge, Madhuri, Rashinkar, Gajanan, Salunkhe, Rajashri
- Tetrahedron letters 2012 v.53 no.22 pp. 2756-2760
- ambient temperature, catalysts, chemical reactions, chemical structure, humans, pyrazines, quinoxalines, solvents, synthesis
- A new Brönsted acid hydrotrope combined catalyst (BAHC) has been developed and applied in acid catalyzed synthesis of pyrido[2,3-b]pyrazines and quinoxalines in an aqueous medium at ambient temperature with excellent yields. Interestingly, the catalyst can be easily recovered after the reactions and reused. Furthermore, BAHC catalyst worked well and avoids the use of organic solvents. We have reported herein the synthetic pathway which has less disastrous effect in the atmosphere and human survival.