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Optimized Liebeskind–Srogl coupling reaction between dihydropyrimidines and tributyltin compounds

Author:
Sun, Qi, Suzenet, Franck, Guillaumet, Gérald
Source:
Tetrahedron letters 2012 v.53 no.22 pp. 2694-2698
ISSN:
0040-4039
Subject:
chemical reactions, chemical structure, tributyltin
Abstract:
We developed an optimized Liebeskind–Srogl reaction in order to synthesize potentially biologically active 2-aryl-1,4-dihydropyrimidines. The pallado-catalyzed cross-coupling reaction between dihydropyrimidines and tributyltin derivatives appears particularly efficient (67–95% yields) when using CuBr·Me₂S as the copper cofactor.
Agid:
1099360