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Friedel–Crafts alkylation on indolocarbazoles catalyzed by two dimethylallyltryptophan synthases from Aspergillus
- Yu, Xia, Yang, Aigang, Lin, Wenhan, Li, Shu-Ming
- Tetrahedron letters 2012 v.53 no.50 pp. 6861-6864
- Aspergillus clavatus, Aspergillus fumigatus, alkylation, chemical structure, enzymes, organic compounds
- Prenylated indolocarbazoles have been reported neither from natural sources, nor by chemical synthetic approaches. In this Letter, we report a regiospecific prenylation of indolocarbazoles at the para-position of the indole N-atom by two recombinant enzymes from the dimethylallyltryptophan synthase (DMATS) superfamily, that is, 5-DMATS from Aspergillus clavatus and FgaPT2 from Aspergillus fumigatus.