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The effect of rotavirus immunization on rotavirus gastroenteritis hospitalization rates in military dependents

Author:
Eberly, Matthew D., Gorman, Greg H., Eide, Matilda B., Olsen, Cara H., Rajnik, Michael
Source:
Vaccine 2011 v.29 no.4 pp. 650-659
ISSN:
0264-410X
Subject:
children, gastroenteritis, immunization, infants, vaccines, United States
Abstract:
We conducted a retrospective review of all U.S. military dependents less than 5 years old hospitalized with rotavirus-associated gastroenteritis from July 2003 to June 2009. The two post-vaccine seasons showed a significant reduction of 62.4% (95% CI, 58.6–65.8, P<0.001) in rotavirus gastroenteritis hospitalization rate compared to the three pre-vaccine seasons. Infants less than 12 months old showed the greatest reduction in incidence at 75.3%. A substantial decrease was also seen in unvaccinated children as well. Vaccine efficacy against hospitalization was 86.0% (95% CI, 77.7–91.3) after just a single dose. The overwhelming majority of children hospitalized for rotavirus since the introduction of the vaccine (ranging from 91.8 to 100% per season) had not received any of the rotavirus vaccine series.
Agid:
1109924