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Sesquiterpenes inhibiting NO production from Celastrus orbiculatus

Author:
Xu, Jing, Jin, Da-qing, Zhao, Peng, Song, Xiaoqiang, Sun, Zhanping, Guo, Yuanqiang, Zhang, Lei
Source:
Fitoterapia 2012 v.83 no.8 pp. 1302-1305
ISSN:
0367-326X
Subject:
Celastrus orbiculatus, fruits, mice, nitric oxide, sesquiterpenoids, spectroscopy
Abstract:
Two new (1 and 2) and one known (3) β-dihydroagarofuran sesquiterpenes were isolated from the fruits of Celastrus orbicultus Thunb. Their structures were elucidated as 1β,13-diacetoxy-8β,9β-dibenzoyloxy-β-dihydroagarofuran (1), 1β,13-diacetoxy-8α-hydroxy-9β-benzoyloxy-β-dihydroagarofuran (2), and 1β,6α,13-triacetoxy-9α-benzoyloxy-β-dihydroagarofuran (3), on the basis of spectroscopic data analyses. All the compounds exhibited inhibitory effects on LPS-induced nitric oxide production in murine microglial BV-2 cells.
Agid:
1123797