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A new hepatotoxic triterpenoid ketone from Curculigo orchioides

Author:
Jiao, Wei, Chen, Xiaozhen, Wang, Haibo, Lu, Runhua, Shao, Huawu
Source:
Fitoterapia 2013 v.84 pp. 1-5
ISSN:
0367-326X
Subject:
Curculigo orchioides, X-ray diffraction, hepatotoxicity, humans, nuclear magnetic resonance spectroscopy, rhizomes
Abstract:
To investigate hepatotoxic constituents, a new cycloartane-type triterpenoid ketone together with four known components was isolated from rhizomes of Curculigo orchioides. The structures of five compounds were elucidated on the basis of spectroscopic methods, including 1D and 2D NMR, and single-crystal X-ray diffraction analysis. Their hepatotoxicity effects in human hepatic cell line HL-7702 were tested for the first time.
Agid:
1123847