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Bioactive cis-stilbenoids from the tubers of Scirpus yagara

Author:
Liang, Qiao-Li, Lei, Ling-Ling, Cui, Xiaodong, Zou, Nuo-Shu, Duan, Jin-Ao
Source:
Fitoterapia 2013 v.84 pp. 170-173
ISSN:
0367-326X
Subject:
Candida albicans, Scirpus, Staphylococcus aureus, antimicrobial properties, cytotoxicity, ethyl acetate, humans, inhibitory concentration 50, spectroscopy, tubers
Abstract:
Two new cis-stilbenoids, sciryagarol I (1) and II (2) were isolated from the EtOAc extract of the tubers of Scirpus yagara, together with four known compounds. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and comparison with literature information. The compounds 3, 4 and 6 were isolated for the first time from this genus. Some compounds were tested for their cytotoxicity against human tumor cell lines and antimicrobial activity. Compounds 1–4 showed significant cytotoxicity against the Hela cell lines with IC₅₀ values ranging from 7.21 to 61.21μM. 1 and 2 exhibited some antimicrobial activity against Staphylococcus aureus and Candida albicans with uniform MICs of 79.3μl/ml for 2, and 152μl/ml for 1, respectively.
Agid:
1123850