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Characterization of tyrosinase inhibitors in the twigs of Cudrania tricuspidata and their structure–activity relationship study

Author:
Zheng, Zong-Ping, Tan, Hui-Yuan, Chen, Jie, Wang, Mingfu
Source:
Fitoterapia 2013 v.84 pp. 242-247
ISSN:
0367-326X
Subject:
Maclura tricuspidata, branches, electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
The twigs of Cudrania tricuspidata were found to show strong tyrosinase inhibitory activity, and further detailed component analysis resulted in the isolation of a new flavanol glucoside, (2S,3S)-2,3-trans-dihydromorin-7-O-β-d-glucoside (1), plus twenty-seven known compounds (2–28). Their structures were elucidated on the basis of ESI-MS and NMR spectral data. Among the isolated compounds, trans-dihydromorin (8), oxyresveratrol (9), and steppogenin (12) were found to exhibit significant tyrosinase inhibition activities. Moreover, the structure–activity relationship of these isolated compounds was also discussed.
Agid:
1123861