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Cytotoxicity and structure activity relationships of phytosterol from Phyllanthus emblica
- Qi, Wei-Yan, Li, Ya, Hua, Lei, Wang, Ke, Gao, Kun
- Fitoterapia 2013 v.84 pp. 252-256
- Aphanamixis polystachya, Phyllanthus emblica, branches, cytotoxicity, inhibitory concentration 50, leaves, sterols, structure-activity relationships
- Fourteen sterols (1–14), including two new sterols, trihydroxysitosterol (2) and 5α,6β,7α-7α-acetoxysitosterol (3), were isolated from the branches and leaves of Phyllanthus emblica L. The isolated compounds and a structurally related sterol 15 from Aphanamixis grandifolia were screened for cytotoxicity in two tumor cell lines (HL-60 and SMMC-7721) and a non-tumor cell line (HL-7702) using RSB assay. Within the series of phytosterol derivatives tested, compound 15 was the most active, displaying potent cytotoxicity against HL-60 with IC₅₀ of 5.10μmol/L, and most of the active compounds showed selective cytotoxicity against tumor and non-tumor cell lines, especially compound 10 with a safety index of 4.42.