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A novel furanoeremophilane with an unusual oxygen bridge from Senecio nemorensis

Author:
Shi, Baojun, Shi, Ji, Jiang, Hongfang, Chou, Guixin, Wang, Zhengtao
Source:
Fitoterapia 2013 v.84 pp. 11-14
ISSN:
0367-326X
Subject:
Senecio nemorensis, X-ray diffraction, cytotoxicity, oxygen, spectroscopy, transcription factor NF-kappa B
Abstract:
Two new furanoeremophilanes, 1α, 6α-epoxy-9-oxo-10β-hydroxyl-furanoeremophilane (1), and 9-oxo-1α, 6β, 10β-trihydroxy-furanoeremophilane (2) were isolated from Senecio nemorensis. Their structures were elucidated by spectroscopic methods and X-ray crystallography. This is the first report of the isolation of the C1–C6 oxygen bridge of furanoeremophilane. Their cytotoxic effects on BEL7402 and NF-KB cell lines were tested.
Agid:
1123869