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Lanostane triterpenes from cultures of the Basidiomycete Ganoderma orbiforme BCC 22324

Author:
Isaka, Masahiko, Chinthanom, Panida, Kongthong, Surisa, Srichomthong, Kitlada, Choeyklin, Rattaket
Source:
Phytochemistry 2013 v.87 pp. 133-139
ISSN:
0031-9422
Subject:
Ganoderma, Mycobacterium tuberculosis, acids, antibacterial properties, mushrooms, skeleton, triterpenoids
Abstract:
Seven lanostane triterpenoids, ganorbiformins A–G, together with twelve known compounds, were isolated from cultures of the mushroom fungus Ganoderma orbiforme BCC 22324. Ganorbiformin A is an unusual rearranged analog, whereas the other compounds share the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T also exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra (MIC 1.3μM).
Agid:
1135573