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Ceriponols A–K, tremulane sesquitepenes from Ceriporia lacerate HS-ZJUT-C13A, a fungal endophyte of Huperzia serrata

Author:
Ying, You-Min, Shan, Wei-Guang, Zhang, Li-Wen, Zhan, Zha-Jun
Source:
Phytochemistry 2013 v.95 pp. 360-367
ISSN:
0031-9422
Subject:
Ceriporia, Huperzia, cytotoxicity, endophytes, fungi, humans, inhibitory concentration 50, medicinal plants, nuclear magnetic resonance spectroscopy, sesquiterpenoids, stems
Abstract:
Tremulane sesquiterpenes ceriponols A–K, together with three known ones tremulenediol A, 11,12-dihydroxy-1-tremulen-5-one and conocenol B, were isolated from the cultures of Ceriporia lacerate, a fungal endophyte residing in the stems of the medicinal plant Huperzia serrata. Among these isolates, ceriponol B possessed an unprecedent 12-nortremulane skeleton. The structures of all isolates were elucidated by spectroscopic methods, including MS and NMR (1D and 2D) spectroscopic techniques. The cytotoxic activities of ceriponols A–K were evaluated against three human tumor cell lines (HeLa, HepG2, and SGC 7901). Ceriponols F and K exhibited moderate cytotoxicity against all the tested human cancer cell lines with IC50 values ranging from 32.3±0.4 to 173.2±1.5μM, while ceriponol G showed slightly better cytotoxicity against a HeLa cell line.
Agid:
1135749