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Modelling transcriptional networks in leaf senescence

Author:
Penfold, Christopher A., Buchanan-Wollaston, Vicky
Source:
Journal of experimental botany 2014 v.65 no.14 pp. 3859-3873
ISSN:
0022-0957
Subject:
crosslinking, gene expression, leaves, models, prediction, senescence, stress response, transcription (genetics), transcriptome
Abstract:
The process of leaf senescence is induced by an extensive range of developmental and environmental signals and controlled by multiple, cross-linking pathways, many of which overlap with plant stress-response signals. Elucidation of this complex regulation requires a step beyond a traditional one-gene-at-a-time analysis. Application of a more global analysis using statistical and mathematical tools of systems biology is an approach that is being applied to address this problem. A variety of modelling methods applicable to the analysis of current and future senescence data are reviewed and discussed using some senescence-specific examples. Network modelling with a senescence transcriptome time course followed by testing predictions with gene-expression data illustrates the application of systems biology tools.
Agid:
1189234