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Rat traps: filling the toolbox for manipulating the rat genome

Author:
van Boxtel, Ruben, Cuppen, Edwin
Source:
Genome biology 2010 v.11 no.9 pp. 2453
ISSN:
1474-760X
Subject:
gene targeting, genome, mutants, rats
Abstract:
The laboratory rat is rapidly gaining momentum as a mammalian genetic model organism. Although traditional forward genetic approaches are well established, recent technological developments have enabled efficient gene targeting and mutant generation. Here we outline the current status, possibilities and application of these techniques in the rat.
Agid:
1194164