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Rat traps: filling the toolbox for manipulating the rat genome
- van Boxtel, Ruben, Cuppen, Edwin
- Genome biology 2010 v.11 no.9 pp. 2453
- gene targeting, genome, mutants, rats
- The laboratory rat is rapidly gaining momentum as a mammalian genetic model organism. Although traditional forward genetic approaches are well established, recent technological developments have enabled efficient gene targeting and mutant generation. Here we outline the current status, possibilities and application of these techniques in the rat.