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An overview of the serpin superfamily
- Law, Ruby HP, Zhang, Qingwei, McGowan, Sheena, Buckle, Ashley M, Silverman, Gary A, Wong, Wilson, Rosado, Carlos J, Langendorf, Chris G, Pike, Rob N, Bird, Philip I, Whisstock, James C
- Genome biology 2006 v.7 no.5 pp. 1202
- coagulation, enzymes, mammals, mutation, polymers, proteinase inhibitors, proteolysis
- Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive polymers.