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Genome assembly forensics: finding the elusive mis-assembly

Author:
Phillippy, Adam M, Schatz, Michael C, Pop, Mihai
Source:
Genome biology 2008 v.9 no.3 pp. 1917
ISSN:
1474-760X
Subject:
computer software, forensic sciences, genome, genome assembly
Abstract:
We present the first collection of tools aimed at automated genome assembly validation. This work formalizes several mechanisms for detecting mis-assemblies, and describes their implementation in our automated validation pipeline, called amosvalidate. We demonstrate the application of our pipeline in both bacterial and eukaryotic genome assemblies, and highlight several assembly errors in both draft and finished genomes. The software described is compatible with common assembly formats and is released, open-source, at http://amos.sourceforge.net .
Agid:
1196074