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Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour

Author:
WATANABE, MARIA ANGELICA EHARA, NUNES, SANDRA ODEBRECHET VARGAS, AMARANTE, MARLA KARINE, GUEMBAROVSKI, ROBERTA LOSI, ODA, JULIE MASSAYO MAEDA, DE LIMA, KALIL WILLIAM ALVES, FUNGARO, MARIA HELENA PELEGRINELLI
Source:
Journal of genetics 2011 v.90 no.1 pp. 179-185
ISSN:
0022-1333
Subject:
brain, environmental factors, genes, genetic polymorphism, nicotine, pathogenesis, promoter regions, secretion, serotonin
Abstract:
Data suggest that the serotonin (5-hydroxytryptamine, 5-HT) system is implicated in the pathogenesis of multiple neuropsychiatric disorders and may also be involved in smoking behaviour since nicotine increases brain serotonin secretion. It is known that smoking behaviour is influenced by both genetic and environmental factors. The present review examines the role of the serotonin transporter gene (5-HTT) in smoking behaviour and investigating studies that showed association of 5-HTT gene with smoking. This study discusses a polymorphism which has been investigated by many researchers, as the bi-allelic insertion/deletion polymorphism in the 5′- flanking promoter region (5-HTTLPR). This gene has received considerable attention in attempts to understand the molecular determinants of smoking. Therefore, in the present study, the relationship between genetic polymorphism of serotonin transporter in smoking behaviour is reviewed considering the interactive effect of genetic factors.
Agid:
120020