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Carprofen-imprinted monolith prepared by reversible addition–fragmentation chain transfer polymerization in room temperature ionic liquids

Ban, Lu, Han, Xu, Wang, Xian-Hua, Huang, Yan-Ping, Liu, Zhao-Sheng
Analytical and bioanalytical chemistry 2013 v.405 no.26 pp. 8597-8605
crosslinking, ethylene glycol, ionic liquids, molecular imprinting, permeability, polymerization, polymers, room temperature, screening
To obtain fast separation, ionic liquids were used as porogens first in combination with reversible addition–fragmentation chain transfer (RAFT) polymerization to prepare a new type of molecularly imprinted polymer (MIP) monolith. The imprinted monolithic column was synthesized using a mixture of carprofen (template), 4-vinylpyridine, ethylene glycol dimethacrylate, [BMIM]BF₄, and chain transfer agent (CTA). Some polymerization factors, such as template-monomer molar ratio, the degree of crosslinking, the composition of the porogen, and the content of CTA, on the column efficiency and imprinting effect of the resulting MIP monolith were systematically investigated. Affinity screening of structurally similar compounds with the template can be achieved in 200 s on the MIP monolith due to high column efficiency (up to 12,070 plates/m) and good column permeability. Recognition mechanism of the imprinted monolith was also investigated.