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Biosynthesis of biologically active low-molecular weight compounds by fungi of the genus Penicillium (Review)
- Kozlovskii, A. G., Antipova, T. V., Zhelifonova, V. P.
- Applied biochemistry and microbiology 2015 v.51 no.2 pp. 236-241
- Penicillium, bioactive properties, biosynthesis, fungi, metabolites
- The recent data on exometabolite biosynthesis in fungi of the genus Penicillium is summarized. The study of creative species, as well as those isolated from extreme ecotopes, resulted in the identification of a number of novel, biologically active compounds. Alkaloid biosynthesis has been shown to begin on the first day of fungus cultivation and to proceed throughout the cultivation period. Idiophase kinetics was observed for the biosynthesis of polyketide metabolites. The mechanisms of regulation of biosynthesis of promising bioactive compounds are discussed.