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Evaluation of Compositae sp. plants for antioxidant activity, antiinflammatory, anticancer and antiadipogenic activity in vitro

Lee, Je-Hyuk, Choi, Eun Jeong, Park, Hee-Sook, Kim, Gun Hee
Food and agricultural immunology 2014 v.25 no.1 pp. 104-118
Chrysanthemum indicum, Chrysanthemum morifolium, Coreopsis, Rudbeckia laciniata, adipocytes, antioxidant activity, biosynthesis, flavonoids, free radical scavengers, gallic acid, immunology, lipopolysaccharides, macrophages, nitric oxide
Aster spathulifolius, Coreopsis drummondii, Chrysanthemum morifolium, Chrysanthemum boreale, Chrysanthemum indicum and Rudbeckia laciniata var. hortensis had 30–70 mg gallic acid equivalents (GAE)/g dw of the total phenolic contents. Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and reducing powers of tested Compositae plant extract appeared to be linear and consistent with total phenolic/flavonoids compound contents in the same manner with DPPH radical scavenging activity. R. laciniata (200 µg/mL) inhibited nitric oxide (NO) production to approximately 92.8% from lipopolysaccharide (LPS)-stimulated macrophage cells. Although the total phenolic/flavonoids contents and antioxidant activity of R. laciniata is low compared with other Compositae plants, R. laciniata shows the superior inhibitory activity against NO biosynthesis from LPS-induced macrophage cells. For antiobesity activity, C. boreale, C. morifolium and C. drummondii might act to accelerate lipid degradation and to decrease lipid synthesis in 3T3-L1 adipocyte cells, and C. indicum, A. spathulifolius and R. laciniata extract had antiobesity activity to inhibit lipid synthesis in 3T3-L1 adipocyte cells.