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Evaluation of Compositae sp. plants for antioxidant activity, antiinflammatory, anticancer and antiadipogenic activity in vitro

Author:
Lee, Je-Hyuk, Choi, Eun Jeong, Park, Hee-Sook, Kim, Gun Hee
Source:
Food and agricultural immunology 2014 v.25 no.1 pp. 104-118
ISSN:
0954-0105
Subject:
Chrysanthemum indicum, Chrysanthemum morifolium, Coreopsis, Rudbeckia laciniata, adipocytes, antioxidant activity, biosynthesis, flavonoids, free radical scavengers, gallic acid, immunology, lipopolysaccharides, macrophages, nitric oxide
Abstract:
Aster spathulifolius, Coreopsis drummondii, Chrysanthemum morifolium, Chrysanthemum boreale, Chrysanthemum indicum and Rudbeckia laciniata var. hortensis had 30–70 mg gallic acid equivalents (GAE)/g dw of the total phenolic contents. Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and reducing powers of tested Compositae plant extract appeared to be linear and consistent with total phenolic/flavonoids compound contents in the same manner with DPPH radical scavenging activity. R. laciniata (200 µg/mL) inhibited nitric oxide (NO) production to approximately 92.8% from lipopolysaccharide (LPS)-stimulated macrophage cells. Although the total phenolic/flavonoids contents and antioxidant activity of R. laciniata is low compared with other Compositae plants, R. laciniata shows the superior inhibitory activity against NO biosynthesis from LPS-induced macrophage cells. For antiobesity activity, C. boreale, C. morifolium and C. drummondii might act to accelerate lipid degradation and to decrease lipid synthesis in 3T3-L1 adipocyte cells, and C. indicum, A. spathulifolius and R. laciniata extract had antiobesity activity to inhibit lipid synthesis in 3T3-L1 adipocyte cells.
Agid:
1220367