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Two new compounds from an Indonesian sponge Dysidea sp.

Author:
Trianto, Agus, de Voodg, Nicole J., Tanaka, Junichi
Source:
Journal of Asian natural products research 2014 v.16 no.2 pp. 163-168
ISSN:
1477-2213
Subject:
aquatic invertebrates, cytotoxicity, inhibitory concentration 50, spectroscopy
Abstract:
On our joint bioprospecting research on Indonesian marine invertebrates, we found moderate cytotoxicity on an extract of the sponge Dysidea sp. collected at Biak, West Papua. Separation of the extract provided two new compounds, biaketide (1) and debromoantazirine (2), along with four known molecules 3 – 6 . The new structures were elucidated by spectroscopic analyses and by comparison with those reported. Compounds 1 and 2 showed moderate cytotoxicity against NBT-T2 cells with IC ₅₀ values of 8.3 and 4.7 μg ml ⁻ ¹, respectively.
Agid:
1221159