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Two new 20α(H)-ursane-type triterpenoids from Ilex cornuta and their cytotoxic activities

Author:
Wang, Wen-Lian, Zhou, Xi, Liu, Yan-Li, Xu, Qiong-Ming, Li, Xiao-Ran, Yang, Shi-Lin
Source:
Journal of Asian natural products research 2014 v.16 no.2 pp. 175-180
ISSN:
1477-2213
Subject:
Ilex cornuta, cytotoxicity, electrospray ionization mass spectrometry, hydrolysis, nuclear magnetic resonance spectroscopy, roots, triterpenoids
Abstract:
Two new 20α-ursane-type triterpenoids (1 – 2) were isolated from the roots of Ilex cornuta , along with three known triterpenoids (3 – 5). The structures of compounds 1 – 2 were determined as 3β, 23-dihydroxy-20α(H) - urs-12-en-28-oic acid (1), 3β,19α,23-trihydroxy-20α(H) - urs-12-en-28-oic acid 3β- O -α- l -arabinopyranoside (2), on the basis of hydrolysis and spectral evidence, including 1D- and 2D-NMR and high-resolution electrospray ionization mass spectrometry analyses. These pure isolates (1 – 5) were tested for their cytotoxic activities by MTT assay.
Agid:
1221161