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A new flavonoid from the aerial parts of Andrographis paniculata

Author:
Chen, Li-Xia, He, Hao, Xia, Gui-Yang, Zhou, Kai-Lan, Qiu, Feng
Source:
Natural product research 2014 v.28 no.3 pp. 138-143
ISSN:
1478-6427
Subject:
Andrographis paniculata, aerial parts, flavonoids, humans, leukemia, spectroscopy, structure-activity relationships
Abstract:
A new flavonoid, 7,8-dimethoxy-2′-hydroxy-5- O -β- d -glucopyranosyloxyflavone (1), along with 15 known flavonoids (2–16), was isolated from the aerial parts of Andrographis paniculata Nees. Their structures were elucidated on the basis of chemical and spectroscopic analyses. Most of them have uncommon O -substitution patterns involving 5-, 7-, 8-, 2′-, 3′-, 4′- and 5′- O -substituents. The antiproliferative effects of these flavonoids against human leukaemia HL-60 cells were investigated. Among them, 13 was the most active, displaying potent antiproliferative activity with IC ₅₀ of 3.50 μM. The structure–activity relationships of these isolated compounds were discussed.
Agid:
1222417