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A new phenolic glycoside from Juglans mandshurica

Author:
Yao, Dalei, Jin, Mei, Zhang, Changhao, Luo, Jie, Li, Ren, Zheng, Mingshan, Cui, Jiongmo, Li, Gao
Source:
Natural product research 2014 v.28 no.13 pp. 998-1002
ISSN:
1478-6427
Subject:
Juglans, acid hydrolysis, cytotoxicity, glycosides, nuclear magnetic resonance spectroscopy
Abstract:
A new phenolic glycoside, 6- O -(4′-hydroxy-3′,5′-dimethoxybenzoyl)- d -glucopyranose (4), and nine known compounds (1 – 3 and 5 – 10) were isolated from Juglans mandshurica Maxim. Compound structures were elucidated by NMR, HR-ESI-MS and acid hydrolysis. Compounds 5 and 6 are reported from this genus for the first time. Among compounds 1 – 10 , only 1 exhibited cytotoxicity against MGC-803, A549, K562, JAR, HeLa, CaSKi and SiHa cell lines (IC ₅₀: 2.0, 5.3, 2.3, 6.9, 4.0, 6.6 and 2.7 μM, respectively).
Agid:
1222569