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Evaluation of noni (Morinda citrifolia L.) juice antiproliferative activity using the Helianthus tuberosus classical in vitro growth model system

Ferri, M., De Palma, G., Franceschetti, M., Tassoni, A.
Plant biosystems 2013 v.147 no.4 pp. 893-897
traditional medicine, cell growth, Morinda citrifolia, cytotoxicity, explants, dietary supplements, tubers, growth models, antioxidant activity, fruit juices, markets, Helianthus tuberosus
Morinda citrifolia L. (noni) is a tropical plant that has been used for centuries in traditional medicine for numerous purposes and, nowadays, is largely commercialised on the worldwide market as a dietary supplement. Long-term in vitro cultures of Helianthus tuberosus dormant parenchyma explants constitute a classical growth model that can be used to evaluate the proliferative or antiproliferative and/or cytotoxic effects of different mixtures of chemicals present in food or with putative pharmacological applications. Explants of dormant tubers were cultured in vitro with 2%, 10% and 20% (v/v) of noni fruit juice. After four weeks of culture, explant cell growth was reduced 40.5%, 72.5% and 73.9%, respectively, by 2%, 10% and 20% (v/v) of noni juice in comparison to untreated controls. Our results demonstrated that noni fruit juice possesses strong antiproliferative capacity, low cytotoxicity and moderate antioxidant activity.