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Non-viral gene therapy for bone tissue engineering

Author:
Wegman, Fiona, Öner, F. Cumhur, Dhert, Wouter J.A., Alblas, Jacqueline
Source:
Biotechnology & genetic engineering reviews 2013 v.29 no.2 pp. 206-220
ISSN:
2046-5556
Subject:
biotechnology, bone formation, cytotoxicity, gene therapy, genetic engineering, humans, small interfering RNA, tissue engineering, transfection
Abstract:
The possibilities of using gene therapy for bone regeneration have been extensively investigated. Improvements in the design of new transfection agents, combining vectors and delivery/release systems to diminish cytotoxicity and increase transfection efficiencies have led to several successful in vitro , ex vivo and in vivo strategies. These include growth factor or short interfering ribonucleic acid (siRNA) delivery, or even enzyme replacement therapies, and have led to increased osteogenic differentiation and bone formation in vivo . These results provide optimism to consider use in humans with some of these gene-delivery strategies in the near future.
Agid:
1236101