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Pilot study of a potential geroprotector, “Quinton Marine Plasma,” in experiments on cultured cells

Author:
Khokhlov, A. N., Morgunova, G. V., Ryndina, T. S., Coll, F.
Source:
Moscow University biological sciences bulletin 2015 v.70 no.1 pp. 7-11
ISSN:
0096-3925
Subject:
2,4-dinitrophenol, Chinese hamsters, cell proliferation, cultured cells, essential oils, oregano, viability
Abstract:
The effect of isotonic Quinton Marine Plasma (QMP) solution on the growth and “stationary phase aging” (accumulation of “age”-related changes in cultured cells during cell proliferation slowing down within a single passage and subsequent “aging” in the stationary phase of growth) of transformed Chinese hamster cells was studied. No positive effects of QMP on the studied viability indexes of the cultured cells were found in any of the experiments. It is assumed that QMP, like many other potential anti-aging agents the authors studied recently (2,4-dinitrophenol in concentrations that provide mild uncoupling, the essential oil of oregano, hydrated C₆₀-fullerene, etc.), can demonstrate its beneficial effect only at the level of the whole organism, triggering neurohumoral mechanisms that are not present in cytological model systems.
Agid:
1239876