PubAg

Main content area

Role of transcription factors in transdifferentiation of the gastric mucosa

Author:
Vernygorodskyi, S. V., Degtiariova, L. V., Iatsyna, O. I., Blume, Ya. B., Yemets, A. I.
Source:
Cytology and genetics 2015 v.49 no.2 pp. 113-117
ISSN:
0095-4527
Subject:
biopsy, gastric mucosa, phenotype, transcription factors
Abstract:
The analysis of intestinal differentiation transcription factor CDX2 in the gastric mucosa biopsies has been carried out. It was established that CDX2 by its own promoter activation pathway can obtain intestinal phenotype for gastric mucosa cells. The loss of CDX2 expression in the nuclei of metaplastic epithelium may serve as a predictor of gastric mucosa malignization.
Agid:
1243619