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Circulation of prions within dust on a scrapie affected farm

Author:
Gough, Kevin C, Baker, Claire A, Simmons, Hugh A, Hawkins, Steve A, Maddison, Ben C
Source:
Veterinary research 2015 v.46 no.1 pp. 40
ISSN:
1297-9716
Subject:
chronic wasting disease, decontamination, deer, disease transmission, elks, farms, goats, humans, prions, scrapie, sheep
Abstract:
Prion diseases are fatal neurological disorders that affect humans and animals. Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs have a direct link to the transmission of disease. Using protein misfolding cyclic amplification we demonstrate that scrapie PrPSᶜ can be detected within circulating dusts that are present on a farm that is naturally contaminated with sheep scrapie. The presence of infectious scrapie within airborne dusts may represent a possible route of infection and illustrates the difficulties that may be associated with the effective decontamination of such scrapie affected premises.
Agid:
1243751