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Perioperative Synbiotics Decrease Postoperative Complications in Periampullary Neoplasms: A Randomized, Double-Blind Clinical Trial

Author:
Sommacal, Heloisa Martins, Bersch, Vivian Pierri, Vitola, Santo Pascoal, Osvaldt, Alessandro Bersch
Source:
Nutrition and cancer 2015 v.67 no.3 pp. 457-462
ISSN:
1532-7914
Subject:
Bifidobacterium bifidum, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus rhamnosus, antibiotics, clinical trials, fructooligosaccharides, hospitals, morbidity, mortality, neoplasms, nutritional status, patients, postoperative complications, prebiotics, probiotics, prognosis, risk, surgery
Abstract:
Periampullary neoplasms are rapidly progressive tumors with a poor prognosis and high morbidity and mortality rates, which have a negative influence on patient outcomes. Some probiotics and prebiotics have the ability to protect the intestinal barrier and prevent bacterial translocation, infection, and postoperative complications. We evaluated the use of synbiotics in a prospective, double-blind study of patients undergoing surgery for periampullary neoplasms (PNs) and assessed the effect of these agents on nutritional status, postoperative complications, antibiotic use, length of hospital stay, and mortality. Patients were randomized to receive probiotics and prebiotics–synbiotics—group S [ Lactobacillus acidophilus 10, 1 × 10 ⁹CFU, Lactobacillus rhamnosus HS 111, 1 × 10 ⁹ CFU, Lactobacillus casei 10, 1 × 10 ⁹ CFU, Bifidobacterium bifidum , 1 × 10 ⁹CFU, and fructooligosaccharides (FOS) 100 mg]—or placebo–controls—group C, twice daily, for a total of 14 days. Risk, clinical status, and postoperative complication rates were assessed. Twenty-three patients were allocated to each group. The incidence of postoperative infection was significantly lower in group S (6 of 23 patients, 26.1%) than in group C (16 of 23 patients, 69.6%) (P = 0.00). Duration of antibiotic therapy was also shorter in group S (mean = 9 days vs. 15 days in group C; P = 0.01). Noninfectious complications were less common in group S (6 of 23 vs. 14 of 23 patients in group C; P = 0.03). Mean length of hospital stay was 12 ± 5 days in group S vs. 23±14 days in group C (P = 0.00). No deaths occurred in group S, whereas 6 deaths occurred in group C (P = 0.02). Perioperative administration of synbiotics reduces postoperative mortality and complication rates in patients undergoing surgery for PNs.
Agid:
1257948