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Three new sesquiterpene lactones from Inula britannica

Author:
Zhang, Xu-Feng, Du, Jing-Ling, Ren, Jie, Ye, Feng-Mei, Xie, Yang-Guo, Cheng, Xiang-Rong, Yan, Shi-Kai, Jin, Hui-Zi
Source:
Archives of pharmacal research 2015 v.38 no.5 pp. 666-672
ISSN:
0253-6269
Subject:
Inula britannica, aerial parts, eudesmanolides, macrophages, nitric oxide, spectroscopy
Abstract:
One new 1,10-secoeudesmanolide (1), two eudesmanolides (2 and 3), together with nine known compounds (4–12) were isolated from the aerial parts of Inula britannica. The structures of the new compounds were elucidated by detailed spectroscopic analysis, including HRESIMS and 2D-NMR spectroscopic method. In addition, compounds 1–4 were tested for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages.
Agid:
1328811