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Molecular characterization of group A rotavirus strains detected in children with diarrhea admitted to Nigerian hospitals in 2013

Author:
Ianiro, Giovanni, Delogu, Roberto, Baba, Marycelin, Oderinde, Bamidele S., Dawurung, Joshua, Ruggeri, Franco Maria, Fiore, Lucia
Source:
Archives of virology 2015 v.160 no.6 pp. 1511-1517
ISSN:
0304-8608
Subject:
Rotavirus A, children, diarrhea, gastroenteritis, genes, genotype, hospitals, phylogeny, Nigeria
Abstract:
Group A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in children worldwide and cause up to 455,000 deaths annually, mostly in developing countries. During 2013, 66 RVAs from children with AGE admitted to four Nigerian hospitals were investigated. The G3P[6], G1P[8] and G2P[4] genotypes predominated. The VP7 and/or VP4 genes of 18 G3P[6]/[8]/[4], six G2P[4], three G12P[8]/[4], and two G1P[8] RVA strains were sequenced. The G3P[6] strains belonged to lineage G3-III and were different from G3 strains widespread in Asia. Phylogenetic analysis revealed substantial sequence conservation, suggesting continuing evolution and genomic reassortment but no zoonotic RVA transmission from animals.
Agid:
1330361