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Toxicity of hydrolysis products from 3-butenyl glucosinolate in rats

Dietz, H.M., Panigrahi, S., Harris, R.
Journal of agricultural and food chemistry 1991 v.39 no.2 pp. 311-315
mustard meal, oilseed cakes, rapeseed meal, toxicity, food contamination, glucosinolates, hydrolysis, nutritive value, rats, mortality, monogastric livestock
While glucosinolate breakdown products occur only in trace quantities in rapeseed meal from European and North American oil mills, glucosinolate hydrolysis during processing in small South Asian oil mills is very significant. This paper reports a study of the toxicity of breakdown products from 3-butenyl glucosinolate, the major glucosinolate in South Asian rapeseed varieties. The compounds were administered to rats by stomach intubation or intraperitoneal injection. 1-Cyano-3,4-epithiobutane was found to have severe effects on the animals. No toxic effects were registered after the administration of its polymerized form. 4-Pentenenitrile had very little effect on the growth rate of rats, and even at very high doses (600 mg/kg of body weight), no mortalities were recorded. The results from this study support the notion of farmers in South Asian countries that rapeseed cake from traditional oil-expelling processes, during which a large proportion of the glucosinolates are enzymically hydrolyzed, have a higher feed value compared with expellers cake, which contains mainly intact glucosinolates.