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Sapogenins of Allium porrum L

Author:
Fattorusso, E., Lanzotti, V., Magno, S., Taglialatela-Scafati, O.
Source:
Journal of agricultural and food chemistry 1998 v.46 no.12 pp. 4904-4908
ISSN:
0021-8561
Subject:
leeks, Allium porrum, sapogenins, chemical structure, spectral analysis, temporal variation, chemical constituents of plants, sowing date, Italy
Abstract:
A chemical study of the sapogenin content has been conducted on leek, Allium porrum L., sown and collected at different times. As a result of this investigation, a variability in the sapogenin composition depending on the climate was observed. In addition, a novel sapogenin named porrigenin C (1a) and its 25S epimer (1b) have been isolated, together with the previously described sapogenins 2-5 and the known compounds agigenin, diosgenin, beta-chlorogenin, and 24-ethylcholesta-(6-acyl)- 3-O-beta-D-glucoside. The chemical structure of the novel compound was elucidated by a detailed spectroscopic analysis based mainly on 1D and 2D NMR techniques. Porrigenin C showed a considerable antiproliferative activity on four tumor cell lines in vitro.
Agid:
1371376