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Acetophenone glycosides from thyme (Thymus vulgaris L.)

Author:
Wang, M., Kikuzaki, H., Lin, C.C., Kahyaoglu, A., Huang, M.T., Nakatani, N., Ho, C.T.
Source:
Journal of agricultural and food chemistry 1999 v.47 no.5 pp. 1911-1914
ISSN:
0021-8561
Subject:
Thymus vulgaris, aromatic compounds, glycosides, chemical structure, plant extracts, cytotoxicity, DNA replication, leukemia, cell lines, humans, anticarcinogenic activity
Abstract:
Four acetophenone glycosides were isolated from the butanol-soluble fraction of thyme extracts. Their structures were determined by spectral methods (MS, NMR, and 2D-NMR). Among them, two new compounds, 4-hydroxyacetophenone 4-O-[5-O-(3,5-dimethoxy-4-hydroxybenzoyl)-beta-D -apiofuranosyl]-(1 to 2) -beta-D-glucopyranoside (1) and 4-hydroxyacetophenone 4-O-[5-O-(4-hydroxybenzoyl)-beta-D-apiofuranosyl]-(1 to 2)-beta-D-glucopyranoside (2), were determined. Compound 1 showed weak cytotoxicity, inhibiting DNA synthesis of human leukemia cells.
Agid:
1371734